CAS 20734-58-1|1-N,1-N,8-N,8-N-tetramethylnaphthalene-1,8-diamine|1,8-Bis(dimethylamino)naphthalene|1-N,1-N,8-N,8-N-tetramethylnaphthalene-1,8-diamine|N1,N1,N8,N8-Tetramethylnaphthalene-1,8-diamine|...

基本信息

化学结构

分子式

C₁₄H₁₈N₂

分子量

214.30612

精确质量

214.14699859

电荷

InChI

InChI=1S/C14H18N2/c1-15(2)12-9-5-7-11-8-6-10-13(14(11)12)16(3)4/h5-10H,1-4H3

InChIKey

GJFNRSDCSTVPCJ-UHFFFAOYSA-N

Canonic Smiles

CN(c1cccc2c1c(ccc2)N(C)C)C

Isomeric Smiles

N(c1c2c(ccc1)cccc2N(C)C)(C)C

计算属性

JChem

质子受体

质子供体

LogD (pH = 5.5)

2.9614348

LogD (pH = 7.4)

3.175277

Log P

3.1788104

摩尔折射率

71.3654

极化性

27.593422

极化表面积

6.48

可自由旋转的化学键

里宾斯基五规则

true

数据来源

名称和标识

IUPAC标准名

1-N,1-N,8-N,8-N-tetramethylnaphthalene-1,8-diamine

别名

1,8-Bis(dimethylamino)naphthaleneN1,N1,N8,N8-Tetramethylnaphthalene-1,8-diamineProton-sponge1,8-双(二甲基氨基)萘N1,N1,N8,N8-Tetramethylnaphthalene-1,8-diamineN1,N1,N8,N8-Tetramethyl-1,8-naphthalenediamine1,8-Bis(dimethylamino)naphthaleneN,N,N',N'-Tetramethyl-1,8-naphthalenediamineN,N,N’,N’-Tetramethyl-1,8-naphthalenediamineN,N,N’,N’-Tetramethyl-1,8-diaminonaphthaleneN,N,N',N'-TETRAMETHYL-1,8-NAPHTHALENEDIAMINEN,N,N′,N′-Tetramethyl-1,8-naphthalenediamine1,8-bis[Dimethylamino]naphthaleneN,N,N′,N′-四甲基-1,8-萘二胺Proton SpongeProton-sponge®1,8-双二甲氨基萘1,8-Bis(dimethylamino)naphthaleneN,N,N′,N′-四甲基-1,8-萘二胺DMANN,N,N′,N′-Tetramethyl-1,8-naphthalenediamineProton-sponge®

IUPAC传统名

1-N,1-N,8-N,8-N-tetramethylnaphthalene-1,8-diamine

名称和标识

数据登录号

EC号

CAS号

PubChem CID

Chemspider ID

维基百科标题

1,8-Bis(dimethylamino)naphthalene

PubChem SID

1620442202484976224848867

MDL号

MFCD00003920

Beilstein号

396782

数据登录号

化合物性质

分子相关蛋白质

暂无数据

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分子图谱

暂无数据

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描述信息

MP Biomedicals

02195518

A strong base with weak nucleophilic character caused by steric effects.

Wikipedia

1,8-Bis(dimethylamino)naphthalene

Sigma Aldrich

158496

包装
10, 50 g in glass bottle
Application
由于空间位阻效应而具有弱亲核性的强碱。1
法律信息
Proton-sponge 注册商标 Sigma-Aldrich Co. LLC

14795

Other Notes
具有独特性质的胺类强碱（"质子海绵"）1,2
法律信息
Proton-sponge 注册商标 Sigma-Aldrich Co. LLC

TRC

B429760

1,8-Bis(dimethylamino)naphthalene, also referred to as protone sponge, is a lipophilic proton trapping agent. 1,8-Bis(dimethylamino)naphthalene is used in the matrix for mass spectroscopy analysis of lipids and fatty acids.

描述信息

参考文献

PubChem文献

数据源提供

• Shroff, R. et al.: Anal. Chem., 81, 7954 (1982)

• Daniell, H. et al.: Biochem. Biophys. Res. Comm., 107, 1191 (1982)

• The steric strain is relieved on protonation, hence it is one of the strongest organic bases known, but is only weakly nucleophilic: Chem. Commun., 723 (1968). In DMF vic-dibromides are debrominated in high yield: Synth. Commun., 5, 87 (1975).

• Has been used In combination with Diphenylphosphonic azide, A12124, for the conversion of carboxylic acids to isocyanates: Synth. Commun., 23, 335 (1993). Preferred base for the conversion of aliphatic amines to isocyanates with Trichloromethyl chloroformate, A17444.

参考文献

生物活性

PubChem BioAssay

生物活性