CAS 50-28-2|CAS 35380-71-3|ESTRADIOL,U.S.P.|(1S,10R,11S,14S,15S)-15-methyltetracyclo[8.7.0.0^{2,7}.0^{11,15}]heptadeca-2,4,6-triene-5,14-diol|estradiol|(1S,10R,11S,14S,15S)-15-methyltetracyclo[8.7.0...

InChI=1S/C18H24O2/c1-18-9-8-14-13-5-3-12(19)10-11(13)2-4-15(14)16(18)6-7-17(18)20/h3,5,10,14-17,19-20H,2,4,6-9H2,1H3/t14-,15-,16+,17+,18+/m1/s1

VOXZDWNPVJITMN-ZBRFXRBCSA-N

Oc1ccc2c(c1)CC[C@@H]1[C@@H]2CC[C@]2([C@H]1CC[C@@H]2O)C

O[C@@H]1[C@@]2([C@H]([C@H]3[C@H](CC2)c2c(CC3)cc(O)cc2)CC1)C

LogD (pH = 7.4)

3.74

LogD (pH = 5.5)

3.75

Log P

3.75

Rotatable Bonds

H Donor

H Acceptors

Lipinski's Rule of Five

true

Acid pKa

10.33

Polar Surface Area

40.46

Polarizability

32.13

Molar Refractivity

79.90

LOG S

-3.99

(1S,10R,11S,14S,15S)-15-methyltetracyclo[8.7.0.0^{2,7}.0^{11,15}]heptadeca-2,4,6-triene-5,14-diol (1S,10R,11S,14S,15S)-15-methyltetracyclo[8.7.0.0²,⁷.0¹¹,¹⁵]heptadeca-2,4,6-triene-5,14-diol (1S,10R,11S,14S,15S)-15-methyltetracyclo[8.7.0.0^{2,7}.0^{11,15}]heptadeca-2(7),3,5-triene-5,14-diol (1S,10R,11S,14S,15S)-15-methyltetracyclo[8.7.0.0²,⁷.0¹¹,¹⁵]heptadeca-2(7),3,5-triene-5,14-diol (1S,3aS,3bR,9bS,11aS)-11a-methyl-1H,2H,3H,3aH,3bH,4H,5H,9bH,10H,11H,11aH-cyclopenta[a]phenanthrene-1,7-diol

IUPAC Traditional name

estradiol (1S,10R,11S,14S,15S)-15-methyltetracyclo[8.7.0.0²,⁷.0¹¹,¹⁵]heptadeca-2(7),3,5-triene-5,14-diol (-)-estradiol

ESTRADIOL,U.S.P.雌二醇17β-雌二醇1,3,5-雌甾三烯-3,17β-二醇β-雌二醇3,17β-二羟基-1,3,5(10)-雌甾三烯Estradiol雌二醇17β-Oestradiol17β-estradioloestradiolβ-雌二醇17-betaDihydroxyoestrinCis-OestradiolEstradiol ValerateEstradiolDihydrofollicular HormoneDihydroxyestrinEstradiol Cypionateβ-EstradiolEstradiol-17betaD-EstradiolDihydrofolliculinD-OestradiolCis-EstradiolestradiolBeta-EstradiolDihydroxyesterin3,17β-Dihydroxy-1,3,5(10)-estratriene1,3,5-Estratriene-3,17β-diol(8''R'',9''S'',13''S'',14''S'',17''S'')-13-methyl-6,7,8,9,11,12,14,15,16,17-decahydrocyclopenta[''a'']phenanthrene-3,17-diol3,17β-二羟基-1,3,5(10)-雌三烯β-雌二醇半水合物β-Estradiol hemihydratebeta-Estradiol(1S,10R,11S,14S,15S)-15-methyltetracyclo[8.7.0.0^{2,7}.0^{11,15}]heptadeca-2(7),3,5-triene-5,14-diolEvorelEstringEstrogelEstraceCimara17β-EstradiolEstrofem(17β)-Estra-1,3,5(10)-triene-3,17-diolEstradot3,17-EpidihydroxyestratrieneEstradermESTRADIOLcis-estradiolEstradiol-17beta17beta-oestradiol17beta-estradiol17beta-estradiol17beta-estra-1,3,5(10)-triene-3,17-diolEstradiol(17beta)-estra-1,3,5(10)-triene-3,17-diol17beta oestradiolbeta-Estradiol

Compudose 200EsclimSyndiolProfoliol BGynoestrylCombipatchTrial SatOestroglandolNordicolFemestralDermestrilOvahormonRicifonInnofemEstroclimEstrevaEstrofem 2CorpagenVivelle-DOTFemogenGynestrelZerellaOestergonEstringFemtraceFeminoneOvastevolAltradSystenDiogynetsEncoreEstradermEvamistEstrogens, EsterifiedAquadiolCompudose 365Progynon DhTrocosoneSoldepZumenonFollicyclinDiogynPerlatanolEstradurinMenestFemtranLynoralEstroviteProgynon-DhDimenformon ProlongatumGynpolarTradeliaAloraVagifemSisare GelClimaraEvorelOvocyclinExtrasorbSotipoxOvocylinProfoliolGynodiolPrimofolAmnestrogenRitsifonProgynonOestrogynalMicrodiolEstroclim 50EstinylEstraderm TtsDepo-EstradiolSk-EstrogensLamdiolVivelleElestrinFemringDivigelEstrifamEstrogelGynergonEstrasorbEstrofem ForteEstring Vaginal RingOvocyclineBardiolMenorestMenostarGinosedolClimadermOestradiolMacrodiolOestradiol ROestrogelOvasterolEstraceDimenformonAgofollinDelestrogenCompudoseDihydromenformonDihydrotheelinSandrena GelGinediscFemestrolAerodiolFempatchOvociclinaMacrolClimara, Menostar

Pharmacology Properties

Click here to submit data

DB00783

Drug Groups

approved; investigational

Description

Generally refers to the 17-beta-isomer of estradiol, an aromatized C18 steroid with hydroxyl group at 3-beta- and 17-beta-position. Estradiol-17-beta is the most potent form of mammalian estrogenic steroids. In humans, it is produced primarily by the cyclic ovaries and the placenta. It is also produced by the adipose tissue of men and postmenopausal women. The 17-alpha-isomer of estradiol binds weakly to estrogen receptors (receptors, estrogen) and exhibits little estrogenic activity in estrogen-responsive tissues. Various isomers can be synthesized. [PubChem]

Indication

For the treatment of urogenital symptoms associated with post-menopausal atrophy of the vagina (such as dryness, burning, pruritus and dyspareunia) and/or the lower urinary tract (urinary urgency and dysuria).

Pharmacology

Estradiol, the principal intracellular human estrogen, is substantially more active than its metabolites, estrone and estriol, at the cellular level.

Toxicity

Can cause nausea and vomiting, and withdrawal bleeding may occur in females.

Affected Organisms

Humans and other mammals

Biotransformation

Exogenous estrogens are metabolized using the same mechanism as endogenous estrogens. Estrogens are partially metabolized by cytochrome P450.

Absorption

43%

Half Life

36 hours

Protein Binding

>95%

Elimination

Estradiol, estrone and estriol are excreted in the urine along with glucuronide and sulfate conjugates.

References

• Pentikainen V, Erkkila K, Suomalainen L, Parvinen M, Dunkel L: Estradiol acts as a germ cell survival factor in the human testis in vitro. J Clin Endocrinol Metab. 2000 May;85(5):2057-67. [Pubmed]

• Sharpe RM, Skakkebaek NE: Are oestrogens involved in falling sperm counts and disorders of the male reproductive tract? Lancet. 1993 May 29;341(8857):1392-5. [Pubmed]

• Raman JD, Schlegel PN: Aromatase inhibitors for male infertility. J Urol. 2002 Feb;167(2 Pt 1):624-9. [Pubmed]

• Carani C, Qin K, Simoni M, Faustini-Fustini M, Serpente S, Boyd J, Korach KS, Simpson ER: Effect of testosterone and estradiol in a man with aromatase deficiency. N Engl J Med. 1997 Jul 10;337(2):91-5. [Pubmed]

• Behl C, Widmann M, Trapp T, Holsboer F: 17-beta estradiol protects neurons from oxidative stress-induced cell death in vitro. Biochem Biophys Res Commun. 1995 Nov 13;216(2):473-82. [Pubmed]

• Schmidt JW, Wollner D, Curcio J, Riedlinger J, Kim LS: Hormone replacement therapy in menopausal women: Past problems and future possibilities. Gynecol Endocrinol. 2006 Oct;22(10):564-77. [Pubmed]

• Foresta C, Zuccarello D, Biagioli A, De Toni L, Prana E, Nicoletti V, Ambrosini G, Ferlin A: Oestrogen stimulates endothelial progenitor cells via oestrogen receptor-alpha. Clin Endocrinol (Oxf). 2007 Oct;67(4):520-5. Epub 2007 Jun 15. [Pubmed]

• Garcia-Segura LM, Sanz A, Mendez P: Cross-talk between IGF-I and estradiol in the brain: focus on neuroprotection. Neuroendocrinology. 2006;84(4):275-9. Epub 2006 Nov 23. [Pubmed]

External Links

• [Wikipedia]

• [RxList]

• [Drugs.com]

• Schmidt JW, Wollner D, Curcio J, Riedlinger J, Kim LS: Hormone replacement therapy in menopausal women: Past problems and future possibilities. Gynecol Endocrinol. 2006 Oct;22(10):564-77. Pubmed

• Raman JD, Schlegel PN: Aromatase inhibitors for male infertility. J Urol. 2002 Feb;167(2 Pt 1):624-9. Pubmed

• Behl C, Widmann M, Trapp T, Holsboer F: 17-beta estradiol protects neurons from oxidative stress-induced cell death in vitro. Biochem Biophys Res Commun. 1995 Nov 13;216(2):473-82. Pubmed

• Sharpe RM, Skakkebaek NE: Are oestrogens involved in falling sperm counts and disorders of the male reproductive tract? Lancet. 1993 May 29;341(8857):1392-5. Pubmed

• Pentikainen V, Erkkila K, Suomalainen L, Parvinen M, Dunkel L: Estradiol acts as a germ cell survival factor in the human testis in vitro. J Clin Endocrinol Metab. 2000 May;85(5):2057-67. Pubmed

• Garcia-Segura LM, Sanz A, Mendez P: Cross-talk between IGF-I and estradiol in the brain: focus on neuroprotection. Neuroendocrinology. 2006;84(4):275-9. Epub 2006 Nov 23. Pubmed

• http://en.wikipedia.org/wiki/Estradiol

• Lievertz, R.W., et al.: Am. J. Obstet. Gynecol., 156, 1289 (1986)

• Salole, E.G., et al.: Anal. Profiles Drug Subs., 15, 283 (1986)

• Tsukuda, Y. et al., J.C.S.(B), 1968, 1387, (cryst struct)

• Miki, T. et al., Proc. Chem. Soc., London, 1963, 139, (synth)

• Ohrt, J.M. et al., Acta Cryst., 1964, 17, 1611, (cryst struct, derivs)

• Wittstruck, T.A. et al., J.O.C., 1973, 38, 1542, (cmr)

• Eder, U. et al., Chem. Ber., 1976, 109, 2948, (synth)

• IARC Monog., 1979, 21, 279, (tox, rev)

• Collins, M.A. et al., Tet. Lett., 1995, 36, 4467, (synth)

• Hylarides, M.D. et al., J.O.C., 1984, 49, 2744, (synth)

• Martindale, The Extra Pharmacopoeia, 32nd edn., Pharmaceutical Press, 1999, 1455

• Schneider, G. et al., Annalen, 1988, 679, (3-Me ether, synth, pmr, cmr, ir)

• Salole, E.G. et al., Anal. Profiles Drug Subst., 1986, 15, 283, (rev)

• Aldrich Library of 13C and 1H FT NMR Spectra, 1992, 3, 565A; 589B; 600B, (nmr)

• Marker, R.E., J.A.C.S., 1938, 60, 2927, (synth)

• Larner, J.M. et al., Endocrinology (Baltimore), 1985, 117, 1209, (metab)

• Busetta, B. et al., Acta Cryst. B, 1976, 32, 1290, (cryst struct)

• Quinkert, G. et al., Annalen, 1981, 2335; 1982, 1999, (synth)

• Ponold, K. et al., Pharmazie, 1973, 28, 371; 1977, 32, 598; 1979, 34, 2050, (STS 153)

• Negwer, M., Organic-Chemical Drugs and their Synonyms, 7th edn., Akademie-Verlag, 1994, 6627, (synonyms)

• Lewis, R.J., Sax's Dangerous Properties of Industrial Materials, 8th edn., Van Nostrand Reinhold, 1992, BFV325; EDO000; EDP000; EDR000; EDS100; DAZ115; EDO500; EDR500

• Aldrich Library of FT-IR Spectra, 1st edn., 1985, 2, 1055C, (ir)

• Gibson, H. et al., Tet. Lett., 1966, 2321, (synth)

Names and Identifiers

IUPAC name

IUPAC Traditional name

estradiol (1S,10R,11S,14S,15S)-15-methyltetracyclo[8.7.0.0²,⁷.0¹¹,¹⁵]heptadeca-2(7),3,5-triene-5,14-diol (-)-estradiol

Synonyms

Brand Name

API Name

Estradiol

References

PubChem Literature

From Data Sources

• Schmidt JW, Wollner D, Curcio J, Riedlinger J, Kim LS: Hormone replacement therapy in menopausal women: Past problems and future possibilities. Gynecol Endocrinol. 2006 Oct;22(10):564-77. Pubmed

• Raman JD, Schlegel PN: Aromatase inhibitors for male infertility. J Urol. 2002 Feb;167(2 Pt 1):624-9. Pubmed

• Behl C, Widmann M, Trapp T, Holsboer F: 17-beta estradiol protects neurons from oxidative stress-induced cell death in vitro. Biochem Biophys Res Commun. 1995 Nov 13;216(2):473-82. Pubmed

• Sharpe RM, Skakkebaek NE: Are oestrogens involved in falling sperm counts and disorders of the male reproductive tract? Lancet. 1993 May 29;341(8857):1392-5. Pubmed

• Pentikainen V, Erkkila K, Suomalainen L, Parvinen M, Dunkel L: Estradiol acts as a germ cell survival factor in the human testis in vitro. J Clin Endocrinol Metab. 2000 May;85(5):2057-67. Pubmed

• Garcia-Segura LM, Sanz A, Mendez P: Cross-talk between IGF-I and estradiol in the brain: focus on neuroprotection. Neuroendocrinology. 2006;84(4):275-9. Epub 2006 Nov 23. Pubmed

• http://en.wikipedia.org/wiki/Estradiol

• Lievertz, R.W., et al.: Am. J. Obstet. Gynecol., 156, 1289 (1986)

• Salole, E.G., et al.: Anal. Profiles Drug Subs., 15, 283 (1986)

• Tsukuda, Y. et al., J.C.S.(B), 1968, 1387, (cryst struct)

• Miki, T. et al., Proc. Chem. Soc., London, 1963, 139, (synth)

• Ohrt, J.M. et al., Acta Cryst., 1964, 17, 1611, (cryst struct, derivs)

• Wittstruck, T.A. et al., J.O.C., 1973, 38, 1542, (cmr)

• Eder, U. et al., Chem. Ber., 1976, 109, 2948, (synth)

• IARC Monog., 1979, 21, 279, (tox, rev)

• Collins, M.A. et al., Tet. Lett., 1995, 36, 4467, (synth)

• Hylarides, M.D. et al., J.O.C., 1984, 49, 2744, (synth)

• Martindale, The Extra Pharmacopoeia, 32nd edn., Pharmaceutical Press, 1999, 1455

• Schneider, G. et al., Annalen, 1988, 679, (3-Me ether, synth, pmr, cmr, ir)

• Salole, E.G. et al., Anal. Profiles Drug Subst., 1986, 15, 283, (rev)

• Aldrich Library of 13C and 1H FT NMR Spectra, 1992, 3, 565A; 589B; 600B, (nmr)

• Marker, R.E., J.A.C.S., 1938, 60, 2927, (synth)

• Larner, J.M. et al., Endocrinology (Baltimore), 1985, 117, 1209, (metab)

• Busetta, B. et al., Acta Cryst. B, 1976, 32, 1290, (cryst struct)

• Quinkert, G. et al., Annalen, 1981, 2335; 1982, 1999, (synth)

• Ponold, K. et al., Pharmazie, 1973, 28, 371; 1977, 32, 598; 1979, 34, 2050, (STS 153)

• Negwer, M., Organic-Chemical Drugs and their Synonyms, 7th edn., Akademie-Verlag, 1994, 6627, (synonyms)

• Lewis, R.J., Sax's Dangerous Properties of Industrial Materials, 8th edn., Van Nostrand Reinhold, 1992, BFV325; EDO000; EDP000; EDR000; EDS100; DAZ115; EDO500; EDR500

• Aldrich Library of FT-IR Spectra, 1st edn., 1985, 2, 1055C, (ir)

• Gibson, H. et al., Tet. Lett., 1966, 2321, (synth)

Bioactivity

PubChem BioAssay

Registration numbers

MDL Number

CAS Number

EC Number

Beilstein Number

PubChem SID

2489448324894389160964126

Molecule Details

DrugBank

DB00783

Drug Groups

approved; investigational

Description

Indication

Pharmacology

Estradiol, the principal intracellular human estrogen, is substantially more active than its metabolites, estrone and estriol, at the cellular level.

Toxicity

Can cause nausea and vomiting, and withdrawal bleeding may occur in females.

Affected Organisms

Humans and other mammals

Biotransformation

Exogenous estrogens are metabolized using the same mechanism as endogenous estrogens. Estrogens are partially metabolized by cytochrome P450.

Absorption

43%

Half Life

36 hours

Protein Binding

>95%

Elimination

Estradiol, estrone and estriol are excreted in the urine along with glucuronide and sulfate conjugates.

References

• Sharpe RM, Skakkebaek NE: Are oestrogens involved in falling sperm counts and disorders of the male reproductive tract? Lancet. 1993 May 29;341(8857):1392-5. [Pubmed]

• Raman JD, Schlegel PN: Aromatase inhibitors for male infertility. J Urol. 2002 Feb;167(2 Pt 1):624-9. [Pubmed]

• Behl C, Widmann M, Trapp T, Holsboer F: 17-beta estradiol protects neurons from oxidative stress-induced cell death in vitro. Biochem Biophys Res Commun. 1995 Nov 13;216(2):473-82. [Pubmed]

• Garcia-Segura LM, Sanz A, Mendez P: Cross-talk between IGF-I and estradiol in the brain: focus on neuroprotection. Neuroendocrinology. 2006;84(4):275-9. Epub 2006 Nov 23. [Pubmed]

External Links

• [Wikipedia]

• [RxList]

• [Drugs.com]

Unique Ingredient Identifier

Wikipedia Title

IUPHAR ligand ID

KEGG ID

Chemspider ID

LINCS Database

CompTox Database

BindingDB Database

Reaxys Registry

Drug Central Database

1,057

ACToR Database

50-28-273459-61-7

HMDB Database

HMDB0000151

ArrayExpress (Repository of Microarray data)

E-AFMX-12E-AFMX-13

VirtualMetabolicHuman Database

PDBeChem Database

LIPID MAPS Instance

SureChEMBL Database

KEGG DRUG Database

S1709

Research Area: Endocrinology
Biological Activity:
Estradiol is the predominant sex hormone present in females. It is also present in males, being produced as an active metabolic product of testosterone. It represents the major estrogen in humans. Estradiol has not only a critical impact on reproductive and sexual functioning, but also affects other organs including the bones. [1]

MP Biomedicals

05203747

MP Biomedicals Rare Chemical collection

Sigma Aldrich

E2758

Application
β-Estradiol is used to study cell differentiation and transformations (tumorigenicity).
Reconstitution
To prepare a 20 μg/ml stock solution, add 1 ml absolute ethanol to 1 mg β-estradiol; gently swirl to dissolve; add 49 ml sterile medium while mixing.
Physical form
powder-RT; stock-frozen in working aliquots, avoid repeated freeze/thaw
Biochem/physiol Actions
由绝经前卵巢分泌的主要雌激素。雌激素在胚胎形成中以及在青春期，通过调控基因转录，并因此调控蛋白合成，从而指导女性表型的发展。它还可诱导促性腺激素的生成，继而诱导排卵。暴露于雌二醇将增加乳腺癌的发病率以及增加增生。

E8875

包装
1, 5, 25, 100 g in glass bottle
250 mg in glass bottle
Biochem/physiol Actions
由绝经前卵巢分泌的主要雌激素。雌激素在胚胎形成中以及在青春期，通过调控基因转录，并因此调控蛋白合成，从而指导女性表型的发展。它还可诱导促性腺激素的生成，继而诱导排卵。暴露于雌二醇将增加乳腺癌的发病率以及增加增生。
Other Notes
Tandem Mass Spectrometry data independently generated by Scripps Center for Metabolomics is available to view or download in PDF. E8875.pdf Tested metabolites are featured on Scripps Center for Metabolomics METLIN Metabolite Database. To learn more, visit sigma.com/metlin.

E125

Biochem/physiol Actions
由绝经前卵巢分泌的主要雌激素。雌激素在胚胎形成中以及在青春期，通过调控基因转录，并因此调控蛋白合成，从而指导女性表型的发展。它还可诱导促性腺激素的生成，继而诱导排卵。暴露于雌二醇将增加乳腺癌的发病率以及增加增生。

E2257

Application
β-雌二醇可用于研究细胞分化和转化（肿瘤发生）。
Reconstitution
要制备 20μg/mL 的储存液，可加入 1mL 无水乙醇，温和搅拌使之溶解，在搅拌下加入 49mL 无菌培养基。
Physical form
室温下为粉末状；分成小份冻存，以避免使用时反复冷冻/解冻
Biochem/physiol Actions
由绝经前卵巢分泌的主要雌激素。雌激素在胚胎形成中以及在青春期，通过调控基因转录，并因此调控蛋白合成，从而指导女性表型的发展。它还可诱导促性腺激素的生成，继而诱导排卵。暴露于雌二醇将增加乳腺癌的发病率以及增加增生。

E1132

包装
Supplied in amber screw-cap vials
Biochem/physiol Actions
由绝经前卵巢分泌的主要雌激素。雌激素在胚胎形成中以及在青春期，通过调控基因转录，并因此调控蛋白合成，从而指导女性表型的发展。它还可诱导促性腺激素的生成，继而诱导排卵。暴露于雌二醇将增加乳腺癌的发病率以及增加增生。

E1024

Frequently Asked Questions
Live Chat and Frequently Asked Questions are available for this Product.
Biochem/physiol Actions
由绝经前卵巢分泌的主要雌激素。雌激素在胚胎形成中以及在青春期，通过调控基因转录，并因此调控蛋白合成，从而指导女性表型的发展。它还可诱导促性腺激素的生成，继而诱导排卵。暴露于雌二醇将增加乳腺癌的发病率以及增加增生。

250155

Biochem/physiol Actions
The major estrogen secreted by the premenopausal ovary. Estrogens direct the development of the female phenotype in embryogenesis and during puberty by regulating gene transcription and, thus, protein synthesis. It also induces the production of gonadotropins which, in turn, induce ovulation. Exposure to estradiol increases breast cancer incidence and proliferation.

75262

31734

Legal Information
VETRANAL is a trademark of Sigma-Aldrich Co. LLC

TRC

E888000

Estradiol is the major estrogen secreted by the premenopausal ovary.

ChEBI

CHEBI:16469

The 17beta-isomer of estradiol.

VETRANAL™, analytical standard

Suitability

meets USP testing specifications

suitable for cell culture

Purity

≥98%

97%

≥97.0% (HPLC)

95%

Packaging

vial of 250 mg

Potency

0.2-10 ng/mL

Sterility

γ-irradiated

Empirical Formula (Hill Notation)

C18H24O2

C18H24O2 · 0.5H2O

Biological Source

Isol. from ovaries and pregnancy urine. Sex pheromone for mallard ducks

Application(s)

Estradiol (and its semisynthetic esters) are used in estrogen replacement therapy

The most potent of the natural estrogens

Safety Statements

53-45

GHS Precautionary statements

P201-P263-P281-P308+P313

P201-P308+P313

GHS Pictograms

Respiratory sensitization, category 1

Germ cell mutagenicity, categories 1A,1B,2

Carcinogenicity, categories 1A,1B,2

Reproductive toxicity, categories 1A,1B,2

Specific Target Organ Toxicity – Single exposure, categories 1,2

Specific Target Organ Toxicity – Repeated exposure, categories 1,2

Aspiration Hazard, category 1

Personal Protective Equipment

Eyeshields, full-face particle respirator type N100 (US), Gloves, respirator cartridge type N100 (US), type P1 (EN143) respirator filter, type P3 (EN 143) respirator cartridges

Eyeshields, Gloves, type P2 (EN 143) respirator cartridges

GHS Signal Word

Danger

German water hazard class

Risk Statements

60-63-40-64

Storage Temperature

2-8°C

GHS Hazard statements

H351-H360Fd-H362

H350

European Hazard Symbols

Toxic (T)

RTECS

KG2975000

Legal Status

S4 (Au), POM (UK), ?-only (U.S.)

Gene Information

human ... ESR1(2099), ESR2(2100), ESRRB(2103), GPER(2852), SERPINA6(866)mouse ... Esr1(13982), Esr2(13983), Esrra(26379)rat ... Afp(24177), Ar(24208), Esr1(24890), Esr2(25149), Shbg(24775)

human ... ESR1(2099), ESR2(2100), ESRRA(2101), ESRRB(2103), GPER(2852), SERPINA6(866)mouse ... Esr1(13982), Esr2(13983), Esrra(26379)rat ... Afp(24177), Ar(24208), Esr1(24890), Esr2(25149), Shbg(24775)

Mechanism of Action

Estradiol enters cells freely and interacts with a cytoplasmic target cell receptor.

The mRNA interacts with ribosomes to produce specific proteins that express the effect of estradiol upon the target cell.

When the estrogen receptor has bound its ligand it can enter the nucleus of the target cell, and regulate gene transcription which leads to formation of messenger RNA.

Certificate of Analysis

Molecule

ID:663