Substance

ID:449766

Names and Identifiers
Synonyms
Estradiol
IUPAC Traditional name
(1S,10R,11S,14S,15S)-15-methyltetracyclo[8.7.0.02,7.011,15]heptadeca-2(7),3,5-triene-5,14-diol
IUPAC name
(1S,10R,11S,14S,15S)-15-methyltetracyclo[8.7.0.02,7.011,15]heptadeca-2(7),3,5-triene-5,14-diol
Registration numbers
CAS Number
50-28-2
Properties
Pharmacology Properties
Mechanism of Action
Estradiol enters cells freely and interacts with a cytoplasmic target cell receptor.
The mRNA interacts with ribosomes to produce specific proteins that express the effect of estradiol upon the target cell.
When the estrogen receptor has bound its ligand it can enter the nucleus of the target cell, and regulate gene transcription which leads to formation of messenger RNA.
Product Information
Biological Source
Isol. from ovaries and pregnancy urine. Sex pheromone for mallard ducks
Application(s)
Estradiol (and its semisynthetic esters) are used in estrogen replacement therapy
The most potent of the natural estrogens
Molecule Details
No Data Available
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Molecular Spectra
No Data Available
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References
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• Aldrich Library of 13C and 1H FT NMR Spectra, 1992, 3, 565A; 589B; 600B, (nmr)
• Marker, R.E., J.A.C.S., 1938, 60, 2927, (synth)
• Salole, E.G. et al., Anal. Profiles Drug Subst., 1986, 15, 283, (rev)
• Martindale, The Extra Pharmacopoeia, 32nd edn., Pharmaceutical Press, 1999, 1455
• Tsukuda, Y. et al., J.C.S.(B), 1968, 1387, (cryst struct)
• Wittstruck, T.A. et al., J.O.C., 1973, 38, 1542, (cmr)
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• Aldrich Library of FT-IR Spectra, 1st edn., 1985, 2, 1055C, (ir)
• IARC Monog., 1979, 21, 279, (tox, rev)
• Hylarides, M.D. et al., J.O.C., 1984, 49, 2744, (synth)
• Ohrt, J.M. et al., Acta Cryst., 1964, 17, 1611, (cryst struct, derivs)
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• Negwer, M., Organic-Chemical Drugs and their Synonyms, 7th edn., Akademie-Verlag, 1994, 6627, (synonyms)
• Schneider, G. et al., Annalen, 1988, 679, (3-Me ether, synth, pmr, cmr, ir)
• Miki, T. et al., Proc. Chem. Soc., London, 1963, 139, (synth)
• Gibson, H. et al., Tet. Lett., 1966, 2321, (synth)
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