Substance
ID:181074
Names and Identifiers
IUPAC Traditional name
estradiol
Synonyms
Estradiolβ-雌二醇1,3,5-雌甾三烯-3,17β-二醇3,17β-二羟基-1,3,5(10)-雌甾三烯雌二醇17β-雌二醇雌二醇
IUPAC name
(1S,10R,11S,14S,15S)-15-methyltetracyclo[8.7.0.02,7.011,15]heptadeca-2,4,6-triene-5,14-diol
Registration numbers
CAS Number
EC Number
MDL Number
Beilstein Number
PubChem SID
Properties
Physical Property
Melting Point
176-180 °C(lit.)
Safety Information
Risk Statements
60-63-40-64
GHS Precautionary statements
P201-P263-P281-P308+P313
GHS Signal Word
Danger
RTECS
KG2975000
Safety Statements
53-45
European Hazard Symbols
Toxic (T)GHS Pictograms
Respiratory sensitization, category 1
Germ cell mutagenicity, categories 1A,1B,2
Carcinogenicity, categories 1A,1B,2
Reproductive toxicity, categories 1A,1B,2
Specific Target Organ Toxicity – Single exposure, categories 1,2
Specific Target Organ Toxicity – Repeated exposure, categories 1,2
Aspiration Hazard, category 1
German water hazard class
3
Personal Protective Equipment
Eyeshields, Gloves, type P2 (EN 143) respirator cartridges
GHS Hazard statements
H351-H360Fd-H362
Pharmacology Properties
Gene Information
human ... ESR1(2099), ESR2(2100), ESRRB(2103), GPER(2852), SERPINA6(866)mouse ... Esr1(13982), Esr2(13983), Esrra(26379)rat ... Afp(24177), Ar(24208), Esr1(24890), Esr2(25149), Shbg(24775)
Product Information
Suitability
meets USP testing specifications
Molecule Details
Frequently Asked Questions
Live Chat and Frequently Asked Questions are available for this Product.
Biochem/physiol Actions
由绝经前卵巢分泌的主要雌激素。雌激素在胚胎形成中以及在青春期，通过调控基因转录，并因此调控蛋白合成，从而指导女性表型的发展。它还可诱导促性腺激素的生成，继而诱导排卵。暴露于雌二醇将增加乳腺癌的发病率以及增加增生。
Live Chat and Frequently Asked Questions are available for this Product.
Biochem/physiol Actions
由绝经前卵巢分泌的主要雌激素。雌激素在胚胎形成中以及在青春期，通过调控基因转录，并因此调控蛋白合成，从而指导女性表型的发展。它还可诱导促性腺激素的生成，继而诱导排卵。暴露于雌二醇将增加乳腺癌的发病率以及增加增生。
Molecular Spectra
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References
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