Substance

ID:181076

Names and Identifiers
IUPAC Traditional name
estradiol
IUPAC name
(1S,10R,11S,14S,15S)-15-methyltetracyclo[8.7.0.02,7.011,15]heptadeca-2,4,6-triene-5,14-diol
Synonyms
1,3,5-雌甾三烯-3,17β-二醇3,17β-二羟基-1,3,5(10)-雌甾三烯17β-雌二醇雌二醇β-雌二醇β-Estradiol
Registration numbers
CAS Number
50-28-2
EC Number
200-023-8
MDL Number
MFCD00003693
Beilstein Number
1914275
PubChem SID
24894389
Properties
Product Information
Packaging
vial of 250 mg
Grade
analytical standard
Safety Information
German water hazard class
3
GHS Pictograms
GHS08
Respiratory sensitization, category 1
Germ cell mutagenicity, categories 1A,1B,2
Carcinogenicity, categories 1A,1B,2
Reproductive toxicity, categories 1A,1B,2
Specific Target Organ Toxicity – Single exposure, categories 1,2
Specific Target Organ Toxicity – Repeated exposure, categories 1,2
Aspiration Hazard, category 1
GHS Signal Word
Danger
GHS Hazard statements
H351-H360Fd-H362
European Hazard Symbols
Toxic Toxic (T)
Risk Statements
60-63-40-64
Personal Protective Equipment
Eyeshields, full-face particle respirator type N100 (US), Gloves, respirator cartridge type N100 (US), type P1 (EN143) respirator filter, type P3 (EN 143) respirator cartridges
Safety Statements
53-45
RTECS
KG2975000
GHS Precautionary statements
P201-P263-P281-P308+P313
Physical Property
Melting Point
176-180 °C(lit.)
Pharmacology Properties
Gene Information
human ... ESR1(2099), ESR2(2100), ESRRA(2101), ESRRB(2103), GPER(2852), SERPINA6(866)mouse ... Esr1(13982), Esr2(13983), Esrra(26379)rat ... Afp(24177), Ar(24208), Esr1(24890), Esr2(25149), Shbg(24775)
Molecule Details
包装
Supplied in amber screw-cap vials
Biochem/physiol Actions
由绝经前卵巢分泌的主要雌激素。雌激素在胚胎形成中以及在青春期，通过调控基因转录，并因此调控蛋白合成，从而指导女性表型的发展。它还可诱导促性腺激素的生成，继而诱导排卵。暴露于雌二醇将增加乳腺癌的发病率以及增加增生。
Molecular Spectra
No Data Available
Click here to submit data
References
No Data Available
Click here to submit data
Navigation