Cidofovir is an injectable antiviral medication for the treatment of cytomegalovirus (CMV) retinitis in patients with AIDS. It suppresses CMV replication by selective inhibition of viral DNA synthesis. [Wikipedia]
Indication
For the treatment of CMV retinitis in patients with acquired immunodeficiency syndrome (AIDS)
Pharmacology
Cidofovir is a new anti-viral drug. It is classified as a nucleotide analogue and is active against herpes cytomegalovirus (CMV) retinitis infection. Most adults are infected with CMV. Cidofovir suppresses cytomegalovirus (CMV) replication by selective inhibition of viral DNA synthesis.
Toxicity
Kidney damage, fall in the number of white blood cells, decreased platelets
Affected Organisms
Human Immunodeficiency Virus
Absorption
100%
Half Life
2.4 to 3.2 hours
Protein Binding
6%
Distribution
* 537 ± 126 mL/kg [VISTIDE ADMINISTERED WITHOUT PROBENECID] * 410 ± 102 mL/kg [VISTIDE ADMINISTERED WITH PROBENECID]
Research Area: Infection Biological Activity: Cidofovir(Vistide) is an injectable antiviral medication for the treatment of cytomegalovirus (CMV) retinitis. (IC50= 0.94 μM) [1][2] A wild type HCMV laboratory strain (AD 169) and 3 ganciclovir-resistant clinical isolates(generated as a result of Ganciclovir therapy) that are cross-resistant to cidofovir were also included in the cidofovir susceptibility assays. AD 169 showed a cidofovir IC50 value of 0.6 pM, and the ganciclovir- resistant isolates showed cidofovir IC50 values ranging from 2.3 to 16 pM. [3]
An injectable antiviral medication for the treatment of cytomegalovirus (CMV) retinitis in patients with AIDS. It suppresses CMV replication by selective inhibition of viral DNA polymerase and therefore prevention of viral replication and transcription. I
Cytosine substituted at the 1 position by a 3-hydroxy-2-(phosphonomethoxy)propyl group (S configuration). A nucleoside analogue, it is an injectable antiviral used for the treatment of cytomegalovirus (CMV) retinitis in AIDS patients.
参考文献
PubChem文献
数据源提供
• http://en.wikipedia.org/wiki/Cidofovir
• Ho, H.T. et al.: Mol. Pharmacol., 41, 197 (1996)
• Rahal, F.M. et al.: Ann. Internal Med., 125, 98 (1996)
• Johnson, J.A. et al.: Antimicrob. Agents Chemother., 43, 1190 (1996)
