Drug Groups

approved

Description

Cidofovir is an injectable antiviral medication for the treatment of cytomegalovirus (CMV) retinitis in patients with AIDS. It suppresses CMV replication by selective inhibition of viral DNA synthesis. [Wikipedia]

Indication

For the treatment of CMV retinitis in patients with acquired immunodeficiency syndrome (AIDS)

Pharmacology

Cidofovir is a new anti-viral drug. It is classified as a nucleotide analogue and is active against herpes cytomegalovirus (CMV) retinitis infection. Most adults are infected with CMV. Cidofovir suppresses cytomegalovirus (CMV) replication by selective inhibition of viral DNA synthesis.

Toxicity

Kidney damage, fall in the number of white blood cells, decreased platelets

Affected Organisms

Absorption

100%

Half Life

2.4 to 3.2 hours

Protein Binding

6%

Distribution

* 537 ± 126 mL/kg [VISTIDE ADMINISTERED WITHOUT PROBENECID]
* 410 ± 102 mL/kg [VISTIDE ADMINISTERED WITH PROBENECID]

Clearance

* 179 +/- 23.1 mL/min/1.73 m2 [WITHOUT PROBENECID]
* 148 +/- 38.8 mL/min/1.73 m2 [WITH PROBENECID]

External Links