物质信息
ID:380010
名称和标识
IUPAC传统名
cidofovir
IUPAC标准名
({[(2S)-1-(4-amino-2-oxo-1,2-dihydropyrimidin-1-yl)-3-hydroxypropan-2-yl]oxy}methyl)phosphonic acid
别名
[[(1S)-2-(4-Amino-2-oxo-1(2H)-pyrimidinyl)-1-(hydroxymethyl)ethoxy]methyl]phosphonic Acid Hydrate(S)-1-(3-hydroxy-2-phosphonomethoxypropyl)cytosine HydrateGS 0504 HydrateVistide HydrateCidovir Hydrate(S)-[[2-(4-Amino-2-oxo-1(2H)-pyrimidinyl)-1-(hydroxymethyl)ethoxy]methyl]phosphonic Acid Hydrate(S)-HPMPC HydrateCidofovir Hydrate1-[(S)-3-Hydroxy-2-(phosphonomethoxy)propyl]cytosine Hydrate
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化合物性质
理化性质
外观
White Solid
熔点
256-260°C (dec.)
溶解度
DMSO (Sparingly)
Water (Sparingly)
安全信息
保存条件
Refrigerator
MSDS下载
产品相关信息
质检报告
描述信息
An injectable antiviral medication for the treatment of cytomegalovirus (CMV) retinitis in patients with AIDS. It suppresses CMV replication by selective inhibition of viral DNA polymerase and therefore prevention of viral replication and transcription. I
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参考文献
• Ho, H.T. et al.: Mol. Pharmacol., 41, 197 (1996)
• Rahal, F.M. et al.: Ann. Internal Med., 125, 98 (1996)
• Johnson, J.A. et al.: Antimicrob. Agents Chemother., 43, 1190 (1996)