Biochem/physiol Actions MAO 抑制剂;抑制血小板聚集。 包装 5, 25 g in poly bottle Application Reactant for preparation of: • Organosilane amines as potent inhibitors and structural probes of influenza A virus M2 proton channel1 • Lamellarin D analogues as inibitors of topoisomerase I and potential antitumor agents2 • Azapeptide tocolytic agents as inhibitors of prostaglandin F2α receptor for preventing preterm labor3 • Thiazolidinones spiro-fused to indolin-2-ones as potent and selective inhibitors of Mycobacterium tuberculosis protein tyrosine phosphatase B4 • Orally bioavailable quinoline-based antidiabetic dipeptidyl peptidase IV inhibitors targeting Lys5545 • Pyrimidine nucleoside derivatives with nitric oxide donors as antiviral agents6 • Benzyladenosine compounds targeting adenosine A2A receptor and adenosine transporter for neuroprotection7 • Naphthol derivatives as inhibitors of the vanilloid receptor TRPV1 with improved potency in rat cystometry models of urinary incontinence8
Biochem/physiol Actions MAO 抑制剂;抑制血小板聚集。 Features and Benefits 符合 A.C.S. 的试剂规范。 包装 50, 250 g in poly bottle Application Reactant for preparation of: • Organosilane amines as potent inhibitors and structural probes of influenza A virus M2 proton channel1 • Lamellarin D analogues as inibitors of topoisomerase I and potential antitumor agents2 • Azapeptide tocolytic agents as inhibitors of prostaglandin F2a receptor for preventing preterm labor3 • Thiazolidinones spiro-fused to indolin-2-ones as potent and selective inhibitors of Mycobacterium tuberculosis protein tyrosine phosphatase B4 • Orally bioavailable quinoline-based antidiabetic dipeptidyl peptidase IV inhibitors targeting Lys5545 • Pyrimidine nucleoside derivatives with nitric oxide donors as antiviral agents6 • Benzyladenosine compounds targeting adenosine A2A receptor and adenosine transporter for neuroprotection7 • Naphthol derivatives as inhibitors of the vanilloid receptor TRPV1 with improved potency in rat cystometry models of urinary incontinence8
Biochem/physiol Actions MAO 抑制剂;抑制血小板聚集。 包装 100, 500 g in poly bottle 3 kg in poly drum 3kg 开口塑料桶包装;100g、500g 塑料瓶包装 法律信息 ReagentPlus 注册商标 Sigma-Aldrich Co. LLC
• For a brief feature on uses of this reagent in Organic synthesis, see: Synlett, 1326 (2007).
• For a one-pot synthesis of pyrazoles from aldehydes by cyclization of the intermediate oxime in acidic medium with potassium dihyrogen phosphate, see: Tetrahedron Lett., 47, 43 (2006).
• For examples of preparation of oximes from carbonyl compounds, see: Org. Synth. Coll., 2, 70, 313 (1955); 7, 149 (1990). Dehydration of aldoximes is a valuable route to nitriles. The preparation of an oxime, and dehydration with acetic anhydride, are exemplified for veratraldehyde: Org. Synth. Coll., 2, 622 (1943). For other methods of dehydrating oximes to nitriles, see Benzaldoxime, A12053. Procedures for the one-pot conversion of aldehydes to nitriles, without isolation of the intermediate oxime, include: refluxing the aldehyde with hydroxylamine hydrochloride in formic acid/ sodium acetate: J. Chem. Soc., 1564 (1965); formic acid alone: Synthesis, 112 (1979); in pyridine and toluene, with azeotropic water removal: Synthesis, 190 (1982); in DMF (reflux; aromatics only): Z. Chem., 15, 302 (1975); heating in NMP at 110-115o, effective for aromatic and aliphatic substrates; under these conditions, DMF gave only 20-30% conversion: Synthesis, 586 (1999). A more recent ambient temperature one-pot procedure utilizes DBU in combination with ethyl dichlorophosphate: Synlett, 1317 (2007).
Room Temperature (15-30°C), Desiccate, Store Under Nitrogen
NC3675000
2X
II
2
III
H290-H302-H312-H315-H317-H319-H351-H373-H400
H200-H351-H373-H290-H315-H319-H400-H302-H312-H317
Warning
3
Eyeshields, Faceshields, full-face particle respirator type N100 (US), Gloves, respirator cartridge type N100 (US), type P1 (EN143) respirator filter, type P3 (EN 143) respirator cartridges