CAS 118-00-3|2-amino-9-[(2R,3R,4S,5R)-3,4-dihydroxy-5-(hydroxymethyl)oxolan-2-yl]-6,9-dihydro-1H-purin-6-one|Guanosine|guanosine|2-Amino-9-beta-D-ribofuranosyl-9H-purine-6-1H-one|2-Amino-9-((2R,3R,4...

基本信息

化学结构

分子式

C₁₀H₁₃N₅O₅

分子量

283.24072

精确质量

283.09166854

电荷

0

InChI

InChI=1S/C10H13N5O5/c11-10-13-7-4(8(19)14-10)12-2-15(7)9-6(18)5(17)3(1-16)20-9/h2-3,5-6,9,16-18H,1H2,(H3,11,13,14,19)/t3-,5-,6-,9-/m1/s1

InChIKey

NYHBQMYGNKIUIF-UUOKFMHZSA-N

Canonic Smiles

OC[C@H]1O[C@H]([C@@H]([C@@H]1O)O)n1cnc2c1nc(N)[nH]c2=O

Isomeric Smiles

n1([C@H]2[C@@H]([C@H](O)[C@H](O2)CO)O)c2c(nc1)c(=O)[nH]c(n2)N

计算属性

JChem

LogD (pH = 7.4)

-2.71

LogD (pH = 5.5)

-2.71

Log P

-2.71

可自由旋转的化学键

2

质子供体

5

质子受体

8

里宾斯基五规则

true

Acid pKa

10.16

极化表面积

155.22

极化性

26.14

摩尔折射率

64.62

LOG S

-1.58

数据来源

学术数据

产品目录

数据来源

名称和标识

IUPAC标准名

2-amino-9-[(2R,3R,4S,5R)-3,4-dihydroxy-5-(hydroxymethyl)oxolan-2-yl]-6,9-dihydro-1H-purin-6-one

别名

2-Amino-9-beta-D-ribofuranosyl-9H-purine-6-1H-oneGuanosine2-Amino-9-((2R,3R,4S,5R)-3,4-dihydroxy-5-(hydroxymethyl)tetrahydrofuran-2-yl)-1H-purin-6(9H)-oneGuanine ribosideGuanine-9-β-D-ribofuranosideGuanosine9-(β-D-呋喃核糖基)鸟嘌呤鸟苷9-(β-D-Ribofuranosyl)guanine鸟嘌呤-9-β-D-呋喃核糖苷GuoGuanosineGuanosin2(3H)-imino-9-beta-D-ribofuranosyl-9H-purin-6(1H)-oneguanosine2-amino-9-beta-D-ribofuranosyl-1,9-dihydro-6H-purin-6-oneGuanine ribosideG9-beta-D-ribofuranosyl-guanineguanosineGuanine-9-beta-D-ribofuranoside2-amino-1,9-dihydro-9-beta-D-ribofuranosyl-6H-purin-6-one

IUPAC传统名

guanosine

名称和标识

数据登录号

PubChem CID

6802765135398635

PubChem SID

16207624524895268248952518144918

MDL号

CAS号

EC号

Beilstein号

CHEMBL

CHEBI ID

16750CHEBI:14375CHEBI:42853CHEBI:42840CHEBI:16750CHEBI:5564CHEBI:42847CHEBI:471737CHEBI:24444

医学主题词(MeSH)

Chemspider ID

DrugBank ID

维基百科标题

美国药典/FDA物质标识码

KEGG ID

MetaboLights数据库

MTBLS601MTBLS1051MTBLS1182MTBLS259MTBLS293MTBLS1221MTBLS158MTBLS3927MTBLS1357MTBLS127MTBLS1987MTBLS36MTBLS125MTBLS1093MTBLS428

BRENDA数据库

2.4.1.693.1.4.163.5.4.152.7.1.1436.3.5.22.4.2.82.7.6.14.6.1.194.6.1.182.7.1.213.6.1.113.1.4.522.7.4.223.1.3.12.7.1.114

UniProt数据库

P0AG21B5FI86B0UVM8O16294Q04GD9Q2IJ54Q6ND67Q3YYN1Q6D1U0Q3KHJ2P0A876Q6G9X3B0JJC4A4W0T9Q7MAV4

PDB数据库

1waf7dqn5igj1ih75igi4dt94dtb3cfo4a4r3skz4pz66ya36vwp3trz4xba6vwo

SABIO-RK数据库

811104314420119011951104234812580309187321186

KNApSAcK数据库

C00019679

PubMed文献链接

2151577821774919114345761706052025597711854980118191898214353781592042421671255154713432150035317202332

BKMS React数据库

Reaxys Registry

CompTox数据库

MetaCyc数据库

BRENDA Ligand数据库

SureChEMBL数据库

专利号

EP1930340US2007184068US2007224210US2007225203EP1840132US2007238678US2004014720US2007237781US2003166619WO2007097991US2005020826US2007269406US2007265224US2005288260

Reactom Database

R-HSA-109536R-HSA-109539R-HSA-109387R-HSA-109534R-HSA-109538R-HSA-74249R-HSA-9735789R-HSA-5628807R-HSA-74248R-HSA-109529R-HSA-727749R-HSA-109527R-HSA-727767R-HSA-112034R-HSA-109278

PDBeChem数据库

GMP

IntEnz数据库

EC 2.7.1.73EC 2.4.2.1EC 3.5.4.15EC 2.4.2.15

Gmelin ID

55323

YMDB Database

YMDB00509

Rhea数据库

RHEA:27862RHEA:13233RHEA:12861RHEA:30771RHEA:27710RHEA:27714RHEA:69584RHEA:30559RHEA:29583

ECMDB Database

ECMDB00133

GeneOntology数据库

GO:0008617GO:0046115GO:1905108GO:0006179GO:0046114

BindingDB数据库

50366814

HMDB数据库

HMDB0000133

VirtualMetabolicHuman数据库

gsn

数据登录号

化合物性质

理化性质

熔点

250(dec.)°C

250 °C (dec.)(lit.)

比旋光度

[α]20/D -73±2°, c = 1.5% in 1 M NaOH

[α]20/D -73±2°, c = 1.5% in 0.1 M NaOH

溶解度

0.1 M NaOH: soluble0.1 g/mL, clear, slightly yellow

化合物性质

分子相关蛋白质

分子图谱

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描述信息

Wikipedia

Guanosine

Sigma Aldrich

75903

Other Notes
Currently available only in Europe.
Application
Guanosine is a purine nucleoside that upon sequential phosphoylation (kinases) forms GTP which is used by RNA polymerases to synthesis RNA(s). GTP is also important in a wide range of GTPase-dependent cell signaling processes. Guanosine is used in selective matricies such a guanosine gels (G-gels) for use in capillary electrophoresis chiral selection and other applications.

G6264

Application
For use in cell culture applications as a precursor of GMP, GDP, GTP and cGMP.

G6752

包装
1, 25, 100, 500 g in poly bottle

ChEBI

CHEBI:16750

A purine nucleoside in which guanine is attached to ribofuranose via a beta-N(9)-glycosidic bond.

描述信息

参考文献

PubChem文献

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