CAS 7087-68-5|Ethyldiisopropylamine|N,N-DIISOPROPYLETHYLAMINE|ethylbis(propan-2-yl)amine|N,N-diisopropylethylamine|DIPEA|N-Ethyldiisopropylamine|Diisopropylethylamine |Hunig's base|`Hünig's base'|二...

基本信息

化学结构

分子式

C₈H₁₉N

分子量

129.24316

精确质量

129.15174961

电荷

InChI

InChI=1S/C8H19N/c1-6-9(7(2)3)8(4)5/h7-8H,6H2,1-5H3

InChIKey

JGFZNNIVVJXRND-UHFFFAOYSA-N

Canonic Smiles

CCN(C(C)C)C(C)C

Isomeric Smiles

N(CC)(C(C)C)C(C)C

计算属性

JChem

质子受体

质子供体

LogD (pH = 5.5)

-1.3996065

LogD (pH = 7.4)

-1.0124657

Log P

2.0937433

摩尔折射率

43.0715

极化性

17.036163

极化表面积

3.24

可自由旋转的化学键

里宾斯基五规则

true

数据来源

名称和标识

别名

EthyldiisopropylamineN,N-DIISOPROPYLETHYLAMINEDIPEAN-EthyldiisopropylamineDiisopropylethylamine Hunig's base`Hünig's base'二异丙基乙胺‘Hünig’s base’N-乙基二异丙基胺N-EthyldiisopropylamineN,N-二异丙基乙胺N-Ethyldiisopropylamine solutionHünig 碱Hünigs 碱Hünigs baseN,N-DiisopropylethylamineN-乙基二异丙胺溶液Hünig’s baseN,N-二异丙基乙胺N,N-DiisopropylethylamineN-乙基二异丙胺N-EthyldiisopropylamineN,N-Diisopropylethyl amineDIEAN-Ethyl-N-isopropylpropan-2-amine

IUPAC标准名

ethylbis(propan-2-yl)amine

IUPAC传统名

N,N-diisopropylethylamine

名称和标识

数据登录号

MDL号

Beilstein号

EC号

CAS号

医学主题词(MeSH)

N,N-diisopropylethylamine

Chemspider ID

73565

PubChem CID

81531

维基百科标题

N,N-Diisopropylethylamine

PubChem SID

2486417824879087248726982484548016203933124885522

数据登录号

化合物性质

分子相关蛋白质

暂无数据

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分子图谱

暂无数据

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描述信息

MP Biomedicals

02150915

1 ml = approx. 0.74 gm
Peptide and protein sequencing reagent.

05206050

MP Biomedicals Rare Chemical collection

Wikipedia

N,N-Diisopropylethylamine

Sigma Aldrich

67994

包装
1 L in glass bottle
250 mL in glass bottle

D125806

包装
10 L in comp drum
100, 500 mL in glass bottle
10L、25L 密封复合材料桶包装；500mL 玻璃瓶包装
2.5 L in glass bottle
Application
质子清除剂，用于肽偶联、1烯醇硼化、2钯(0)催化的烯丙基磷酸酯和醋酸酯的烷氧基羰基化，3 以及在烯基砜合成中用作催化剂。4
法律信息
ReagentPlus 注册商标 Sigma-Aldrich Co. LLC

550043

包装
100, 500 mL in glass bottle
2 L in glass bottle
Legal Information
Arkema Inc. 产品
法律信息
ReagentPlus 注册商标 Sigma-Aldrich Co. LLC

387649

包装
1 L in Sure/Seal™
100 mL in Sure/Seal™

496219

包装
100, 500 mL in Sure/Seal™
2 L in Sure/Seal™

描述信息

参考文献

PubChem文献

数据源提供

• Has been recommended as a base for the Horner-Wadsworth-Emmons olefination reaction, where the reagents contain groups sensitive to base-catalyzed epimerization or condensation. The reaction is carried out in the presence of LiCl, and gives high (E):(Z) ratios: Tetrahedron Lett., 25, 2183 (1984).

• Useful base in peptide coupling reactions: J. Am. Chem. Soc., 91, 6488 (1969). See Appendix 6.

• For use in the introduction of TBDMS protecting groups, see tert-Butyldimethylchlorosilane, A13064. Used in preparation of silyl enol ethers from both aldehydes and ketones: Helv. Chim. Acta, 60, 1801 (1977).

• Hindered non-nucleophilic base with high proton affinity: Chem. Ber., 91, 380 (1958).

参考文献

生物活性

PubChem BioAssay

生物活性