化合物信息

S2347 

Research Area: Inflammation
Biological Activity:
Quercetin (Sophoretin) is a PI3K and PKC inhibitor with IC50 of 3.8 μM and 15µg/ml. It strongly abrogated PI3K and Src kinases, mildly inhibited Akt1/2, and slightly affected PKC, p38 and ERK1/2. [1][2] Quercetin is a naturally-occurring polar auxin transport inhibitor with IC50 of 0.8, 16.7, 6.1, 11.36 µM for the inhibition of LDH% release, the inhibition of TNF-induced PMN-EC adhesion, TNF-induced inhibition of DNA synthesis and proliferation. It is a type of plant-based chemical, or phytochemical, known as a flavonol and a plant-derived flavonoid found in fruits, vegetables, leaves and grains. It also may be used as an ingredient in supplements, beverages or foods. In several studies, it may have anti-inflammatory and antioxidant properties, and it is being investigated for a wide range of potential health benefits. [3]References on Quercetin (Sophoretin)[1] Mol Pharmacol, 2001, 59:1138–1146[2] Fitoterapia, 2010, 81:75–80

02152003 

Dihydrate
Crystalline
Inhibitor of protein tyrosine kinases.

05203879 

MP Biomedicals Rare Chemical collection

Q0125 

Frequently Asked Questions
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Biochem/physiol Actions
槲皮素二水合物是具有抗癌活性的黄酮类化合物。槲皮素为线粒体 ATP 酶和磷酸二酯酶抑制剂。它可抑制 PI3 激酶活性并且轻微抑制 PIP 激酶活性。槲皮素对癌细胞系具有抗增殖作用，通过 II 型雌激素受体降低癌细胞的生长，并且阻滞细胞周期晚期 G1 相中人类白血病 T 细胞。

00200595 

Application
草药产品分析的标准品。
General description
由 HWI Analytik 生产和检验 证书上注明了由定量 NMR 确定的准确含量
Biochem/physiol Actions
槲皮素二水合物是具有抗癌活性的黄酮类化合物。槲皮素为线粒体 ATP 酶和磷酸二酯酶抑制剂。它可抑制 PI3 激酶活性并且轻微抑制 PIP 激酶活性。槲皮素对癌细胞系具有抗增殖作用，通过 II 型雌激素受体降低癌细胞的生长，并且阻滞细胞周期晚期 G1 相中人类白血病 T 细胞。

Q509500 

A flavonoid with anticancer activity. It is a mitochondrial ATPase and phosphodiesterase inhibitor. It Inhibits PI3-kinase activity and slightly inhibits PIP kinase activity. Quercetin has antiproliferative effects on cancer cell lines, reduces cancer cel