CAS 52645-53-1|Elimite|permethrin|permethrin|Acticin Cream|Nix|Permethrin|Elimite Cream|PerFoam|(3-phenoxyphenyl)methyl 3-(2,2-dichloroethenyl)-2,2-dimethylcyclopropane-1-carboxylate|Nix Cream Rinse...

基本信息

化学结构

分子式

C₂₁H₂₀Cl₂O₃

分子量

391.2877

精确质量

390.07894986

电荷

InChI

InChI=1S/C21H20Cl2O3/c1-21(2)17(12-18(22)23)19(21)20(24)25-13-14-7-6-10-16(11-14)26-15-8-4-3-5-9-15/h3-12,17,19H,13H2,1-2H3

InChIKey

RLLPVAHGXHCWKJ-UHFFFAOYSA-N

Canonic Smiles

ClC(=CC1C(C1(C)C)C(=O)OCc1cccc(c1)Oc1ccccc1)Cl

Isomeric Smiles

ClC(=CC1C(C1C(=O)OCc1cc(Oc2ccccc2)ccc1)(C)C)Cl

计算属性

JChem

质子受体

质子供体

LogD (pH = 5.5)

5.6960993

LogD (pH = 7.4)

5.6960993

Log P

5.6960993

摩尔折射率

114.2824

极化性

40.698902

极化表面积

35.53

可自由旋转的化学键

里宾斯基五规则

false

ALOGPS 2.1

Log P

6.24

LOG S

-6.75

溶解度

6.91e-05 g/l

数据来源

名称和标识

商标名

ElimiteNixNix Cream RinsePerFoamActicin CreamElimite Cream

别名

permethrinPermethrinAmbushPERMETHRIN MIXTURES OF ISOMERSPounce3-Phenoxybenzyle (1RS)-cis, trans-3-(2,2-dichlorovinyl)-2,2-dimethylcyclopropane carboxylatePermethrin氯菊脂Permethrin (isomers) solution氯菊脂（异构体）溶液Permethrin (isomers)氯菊脂氯菊脂（异构体）

IUPAC传统名

permethrin

IUPAC标准名

(3-phenoxyphenyl)methyl 3-(2,2-dichloroethenyl)-2,2-dimethylcyclopropane-1-carboxylate

名称和标识

数据登录号

MDL号

MFCD00041809

PubChem SID

248716304650537424899290248680011609678322486934924869115

Beilstein号

CAS号

EC号

PubChem CID

维基百科标题

DrugBank ID

KEGG ID

Chemspider ID

ATC码

CHEBI ID

美国药典/FDA物质标识码

CHEMBL

数据登录号

化合物性质

产品相关信息

化合物性质

分子相关蛋白质

暂无数据

点击上传数据

分子图谱

暂无数据

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描述信息

MP Biomedicals

02158977

Mixture of isomers
A weakly active Type I pyrethrin for use as a "negative" control for the inhibition of calcineurin (protein phosphatase 2B) by Type II pyrethrins.

Wikipedia

Permethrin

DrugBank

DB04930

Drug Groups

approved; investigational

Description

A pyrethroid insecticide commonly used in the treatment of lice infestations and scabies. It is a yellow to light orange-brown, low melt-ing solid or viscous liquid.

Indication

For the treatment of infestation with Sarcoptes scabiei (scabies).

Pharmacology

Permethrin, a pyrethroid, is active against a broad range of pests including lice, ticks, fleas, mites, and other arthropods.

Toxicity

Oral, rat LD₅₀: 430 - 4000 mg/kg; skin, rabbit LD₅₀: 2000 mg/kg.

Affected Organisms

Scabies (Sarcoptes scabei) and other insects

Biotransformation

Rapidly metabolized by ester hydrolysis to inactive metabolites which are excreted primarily in the urine.

Absorption

Poorly absorbed through the skin.

Elimination

Permethrin is rapidly metabolized by ester hydrolysis to inactive metabolites which are excreted primarily in the urine.

References

• Abedin S, Narang M, Gandhi V, Narang S: Efficacy of permethrin cream and oral ivermectin in treatment of scabies. Indian J Pediatr. 2007 Oct;74(10):915-6. [Pubmed]

External Links

• [Wikipedia]

• [RxList]

• [Drugs.com]

Sigma Aldrich

45614

法律信息
PESTANAL 注册商标 Sigma-Aldrich Laborchemikalien GmbH

45893

法律信息
PESTANAL 注册商标 Sigma-Aldrich Laborchemikalien GmbH

描述信息

参考文献

PubChem文献

数据源提供

• Abedin S, Narang M, Gandhi V, Narang S: Efficacy of permethrin cream and oral ivermectin in treatment of scabies. Indian J Pediatr. 2007 Oct;74(10):915-6. Pubmed

参考文献

生物活性

PubChem BioAssay

生物活性

名称和标识

商标名

ElimiteNixNix Cream RinsePerFoamActicin CreamElimite Cream

别名

IUPAC传统名

permethrin

IUPAC标准名

(3-phenoxyphenyl)methyl 3-(2,2-dichloroethenyl)-2,2-dimethylcyclopropane-1-carboxylate

数据登录号

MDL号

MFCD00041809

PubChem SID

248716304650537424899290248680011609678322486934924869115

Beilstein号

CAS号

EC号

PubChem CID

维基百科标题

DrugBank ID

KEGG ID

Chemspider ID

ATC码

CHEBI ID

美国药典/FDA物质标识码

CHEMBL

描述信息

Mixture of isomers
A weakly active Type I pyrethrin for use as a "negative" control for the inhibition of calcineurin (protein phosphatase 2B) by Type II pyrethrins.

Wikipedia

Permethrin

DrugBank

DB04930

Drug Groups

approved; investigational

Description

A pyrethroid insecticide commonly used in the treatment of lice infestations and scabies. It is a yellow to light orange-brown, low melt-ing solid or viscous liquid.

Indication

For the treatment of infestation with Sarcoptes scabiei (scabies).

Pharmacology

Permethrin, a pyrethroid, is active against a broad range of pests including lice, ticks, fleas, mites, and other arthropods.

Toxicity

Oral, rat LD₅₀: 430 - 4000 mg/kg; skin, rabbit LD₅₀: 2000 mg/kg.

Affected Organisms

Scabies (Sarcoptes scabei) and other insects

Biotransformation

Rapidly metabolized by ester hydrolysis to inactive metabolites which are excreted primarily in the urine.

Absorption

Poorly absorbed through the skin.

Elimination

Permethrin is rapidly metabolized by ester hydrolysis to inactive metabolites which are excreted primarily in the urine.

References

• Abedin S, Narang M, Gandhi V, Narang S: Efficacy of permethrin cream and oral ivermectin in treatment of scabies. Indian J Pediatr. 2007 Oct;74(10):915-6. [Pubmed]

External Links

• [Wikipedia]

• [RxList]

• [Drugs.com]

Sigma Aldrich

45614

法律信息
PESTANAL 注册商标 Sigma-Aldrich Laborchemikalien GmbH

45893

法律信息
PESTANAL 注册商标 Sigma-Aldrich Laborchemikalien GmbH

参考文献

PubChem文献

数据源提供

• Abedin S, Narang M, Gandhi V, Narang S: Efficacy of permethrin cream and oral ivermectin in treatment of scabies. Indian J Pediatr. 2007 Oct;74(10):915-6. Pubmed

生物活性

PubChem BioAssay

化合物性质

产品相关信息

化合物信息

ID:4400