物质信息
ID:4535
名称和标识
商标名
Acticin CreamElimite CreamPerFoamElimiteNixNix Cream Rinse
别名
Permethrinpermethrin
IUPAC标准名
(3-phenoxyphenyl)methyl 3-(2,2-dichloroethenyl)-2,2-dimethylcyclopropane-1-carboxylate
IUPAC传统名
permethrin
化合物性质
理化性质
溶解度
6e-06 mg/mL at 20 oC [USDA PESTICIDE PROP DATABASE]
疏水性(logP)
6.50 [HANSCH,C ET AL. (1995)]
描述信息
Drug Groups
approved; investigational
Description
A pyrethroid insecticide commonly used in the treatment of lice infestations and scabies. It is a yellow to light orange-brown, low melt-ing solid or viscous liquid.
Indication
For the treatment of infestation with Sarcoptes scabiei (scabies).
Pharmacology
Permethrin, a pyrethroid, is active against a broad range of pests including lice, ticks, fleas, mites, and other arthropods.
Toxicity
Oral, rat LD50: 430 - 4000 mg/kg; skin, rabbit LD50: 2000 mg/kg.
Affected Organisms
Scabies (Sarcoptes scabei) and other insects
Biotransformation
Rapidly metabolized by ester hydrolysis to inactive metabolites which are excreted primarily in the urine.
Absorption
Poorly absorbed through the skin.
Elimination
Permethrin is rapidly metabolized by ester hydrolysis to inactive metabolites which are excreted primarily in the urine.
References
•
Abedin S, Narang M, Gandhi V, Narang S: Efficacy of permethrin cream and oral ivermectin in treatment of scabies. Indian J Pediatr. 2007 Oct;74(10):915-6.
[Pubmed]
External Links
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参考文献
• Abedin S, Narang M, Gandhi V, Narang S: Efficacy of permethrin cream and oral ivermectin in treatment of scabies. Indian J Pediatr. 2007 Oct;74(10):915-6. Pubmed