Acetohydroxamic Acid, a synthetic drug derived from hydroxylamine and ethyl acetate, is similar in structure to urea. In the urine, it acts as an antagonist of the bacterial enzyme urease. Acetohydroxamic Acid has no direct antimicrobial action and does not acidify urine directly. It is used, in addition to antibiotics or medical procedures, to treat chronic urea-splitting urinary infections.
Indication
Used, in addition to antibiotics or medical procedures, to treat chronic urea-splitting urinary infections.
Pharmacology
Acetohydroxamic Acid, a synthetic drug derived from hydroxylamine and ethyl acetate, is similar in structure to urea. In the urine, it acts as an antagonist of the bacterial enzyme urease. Acetohydroxamic Acid has no direct antimicrobial action and does not acidify urine directly.
Toxicity
Oral, rat: LD50 = 4.8gm/kg. Symptoms of overdose include anorexia, malaise, lethargy, diminished sense of wellbeing, tremor, anxiety, nausea, and vomiting.
Affected Organisms
Enteric bacteria and other eubacteria
Biotransformation
35-65% of oral dose excreted unchanged in urine (which provides the drug's therapeutic effect).
Absorption
Well absorbed from the GI tract following oral administration.
Hygroscopic, -20°C Freezer, Under Inert Atmosphere
61
Danger
53-45
53-20-36-45
P201-P308+P313
P281-P201-P202-P308+P313-P405-P501A
有毒 (T)
Eyeshields, Gloves, type P2 (EN 143) respirator cartridges
Eyeshields, full-face particle respirator type N100 (US), Gloves, respirator cartridge type N100 (US), type P1 (EN143) respirator filter, type P3 (EN 143) respirator cartridges
有毒 (T)