Biochem/physiol Actions Mode of Action: Inhibits cell wall synthesis.Antimicrobial spectrum: Gram-positive cocci.Mode of Resistance: Cephalosporinase production. Mode of Action: Inhibits cell wall synthesis.Antimicrobial spectrum: Gram-positive cocci.Mode of Resistance: Cephalosporinase production. Other Notes First generation cephalosporin antibiotic. General description Cephalotin is a first generation cephalosporin antibiotic. Protocols & Applications Antibiotic Selector for application, solubility, solution stability, working concentration, and mode of action information
Biochem/physiol Actions Cephalothin is a first-generation cephalosporin antibiotic that disrupts the synthesis of the peptidoglycan layer of bacterial cell walls. It is effective against gram-positive and gram-negative bacteria. Mode of Resistance: Cephalosporinase production. Mode of Action: Inhibits cell wall synthesis.Antimicrobial spectrum: Gram-positive cocci.Mode of Resistance: Cephalosporinase production. Other Notes First generation cephalosporin antibiotic. Application Cephalothis is used to study the mechanism of liposome encapsulated antibiotics 1, strategies for co-opting β-lactamases of Gram-negative bacteria for treatment of antibiotics 2, and for immunology studies in relation to antibiotics 3. It is used to study the effect of expression, binding and inhibition of penicillin-binding proteins especially PBP6 on bacterial cell wall mucopeptide synthesis. Protocols & Applications Antibiotic Selector for application, solubility, solution stability, working concentration, and mode of action information
A first generation cephalosporin antibiotic with a wide range antibacterial activity. It is effective against gram-positive and gram-negative bacteria, and has been tested in respiratory disease and neuromuscular junction studies.
参考文献
PubChem文献
数据源提供
• Shibata, K., et al.: J. Antibiot., 50, 135 (1997)
• Pichardo, C., et al.: Eur. J. Clin. Microbiol. Infect. Dis., 30, 289 (1997)
• Farra, A., et al.: Int. J. Antimicrob. Agents., 31, 427 (1997)