Biochem/physiol Actions
Cephalothin is a first-generation cephalosporin antibiotic that disrupts the synthesis of the peptidoglycan layer of bacterial cell walls. It is effective against gram-positive and gram-negative bacteria. Mode of Resistance: Cephalosporinase production.
Mode of Action: Inhibits cell wall synthesis.Antimicrobial spectrum: Gram-positive cocci.Mode of Resistance: Cephalosporinase production.
Other Notes
First generation cephalosporin antibiotic.
Application
Cephalothis is used to study the mechanism of liposome encapsulated antibiotics 1, strategies for co-opting β-lactamases of Gram-negative bacteria for treatment of antibiotics 2, and for immunology studies in relation to antibiotics 3. It is used to study the effect of expression, binding and inhibition of penicillin-binding proteins especially PBP6 on bacterial cell wall mucopeptide synthesis.
Protocols & Applications
Antibiotic Selector for application, solubility, solution stability, working concentration, and mode of action information