Nutritional factor found in milk, eggs, malted barley, liver, kidney, heart, and leafy vegetables. The richest natural source is yeast. It occurs in the free form only in the retina of the eye, in whey, and in urine; its principal forms in tissues and cells are as flavin mononucleotide and flavin-adenine dinucleotide. [PubChem]
Indication
For the treatment of ariboflavinosis (vitamin B2 deficiency).
Pharmacology
Riboflavin or vitamin B2 is an easily absorbed, water-soluble micronutrient with a key role in maintaining human health. Like the other B vitamins, it supports energy production by aiding in the metabolising of fats, carbohydrates, and proteins. Vitamin B2 is also required for red blood cell formation and respiration, antibody production, and for regulating human growth and reproduction. It is essential for healthy skin, nails, hair growth and general good health, including regulating thyroid activity. Riboflavin also helps in the prevention or treatment of many types of eye disorders, including some cases of cataracts.
Affected Organisms
Humans and other mammals
Biotransformation
Hepatic.
Absorption
Vitamin B2 is readily absorbed from the upper gastrointestinal tract.
Half Life
66-84 minutes
Protein Binding
60%
References
•
Zempleni J, Galloway JR, McCormick DB: Pharmacokinetics of orally and intravenously administered riboflavin in healthy humans. Am J Clin Nutr. 1996 Jan;63(1):54-66.
[Pubmed]
Research Area: Metabolic Disease Biological Activity: Riboflavin (vitamin B2) is an easily absorbed micronutrient with a key role in maintaining health in humans and other animals. Riboflavin (vitamin B2) is the central component of the cofactors FAD and FMN, and is therefore required by all flavoproteins. As such, riboflavin (vitamin B2) is required for a wide variety of cellular processes. Riboflavin (vitamin B2) plays a key role in energy metabolism, and for the metabolism of fats, ketone bodies, carbohydrates, and proteins. [1][2]
Caution Riboflavin is a photo-sensitive component of cell culture media. Other Notes This product has been qualified for use in plant cell culture applications. General description Riboflavin is one of the essential water soluble vitamins. It is made by all plants and many microorganism, but not by higher animals. Riboflavin is the precursor for the active enzyme cofactors riboflavin 5′-monophosphate (also called flavinmononucleotide or FMN) and flavin adenine dinucleotide (FAD). Flavin nucleotides function as prosthetic groups of oxidation-reduction enzymes known as flavoproteins. These enzymes function in the oxidative degradation of pyruvate, fatty acids, and amino acids. The flavins are reversibly reduced by the action of flavoproteins to form FMNH2 and FADH2.
Application Enzyme cofactor 包装 1 kg in poly drum 500 g in poly drum 5, 25, 100 g in glass bottle Biochem/physiol Actions Riboflavin is a key component of the redox cofactors flavin adenine dinucleotide (FAD) and flavin mononucleotide (FMN) that are used by a wide variety of flavoprotein oxidoreductases, dehydrogenase(s), decarboxylase(s) and electron transporters.
Application Riboflavin is suitable as a photopolymerization reagent in PAGE by forming free radicals in aqueous solution in the presence of light. Riboflavin photodecomposes to leucoflavin. No free radicals are formed in the absence of oxygen but traces of oxygen allows for leucoflavin to reoxidize with free-radical generation. The catalysts TEMED or DMAPN are commonly added to speed up the free radical formation. The free radicals will cause acrylamide and bis-acrylamide to polymerize to form a gel matrix which can be used for sieving macromolecules. Riboflavin is commonly used in the stacking gel for non-denaturing PAGE because native proteins can be sensitive to persulfate ions from ammonium persulfate. Another advantage of riboflavin over ammonium persulfate is that it will not start polymerizing until the gel is illuminated.
Nutritional factor found in milk, eggs, malted barley, liver, kidney, heart, leafy vegetables. Richest natural source is yeast. Minute amounts present in all plant and animal cells. Vitamin (enzyme cofactor).
References
PubChem Literature
From Data Sources
• Zempleni J, Galloway JR, McCormick DB: Pharmacokinetics of orally and intravenously administered riboflavin in healthy humans. Am J Clin Nutr. 1996 Jan;63(1):54-66. Pubmed
• Zempleni J et al. Am J Clin Nutr. 1996 Jan;63(1):54-66.
• Unna, K., et al.: J. Pharmacol. Exp. Ther., 76, 75 (1942)
• Al-Shammary, F.J., et al.: Anal. Profiles Drug Subs., 19, 429 (1942)
• Rivlin, et al.: N. Engl. J. Med., 283, 463 (1942)
