化合物信息

DB00140 

S2540  

Research Area: Metabolic Disease
Biological Activity:
Riboflavin (vitamin B2) is an easily absorbed micronutrient with a key role in maintaining health in humans and other animals. Riboflavin (vitamin B2) is the central component of the cofactors FAD and FMN, and is therefore required by all flavoproteins. As such, riboflavin (vitamin B2) is required for a wide variety of cellular processes. Riboflavin (vitamin B2) plays a key role in energy metabolism, and for the metabolism of fats, ketone bodies, carbohydrates, and proteins. [1][2]

Riboflavin 

R9881 

Caution
Riboflavin is a photo-sensitive component of cell culture media.
Other Notes
This product has been qualified for use in plant cell culture applications.
General description
Riboflavin is one of the essential water soluble vitamins. It is made by all plants and many microorganism, but not by higher animals. Riboflavin is the precursor for the active enzyme cofactors riboflavin 5′-monophosphate (also called flavinmononucleotide or FMN) and flavin adenine dinucleotide (FAD). Flavin nucleotides function as prosthetic groups of oxidation-reduction enzymes known as flavoproteins. These enzymes function in the oxidative degradation of pyruvate, fatty acids, and amino acids. The flavins are reversibly reduced by the action of flavoproteins to form FMNH2 and FADH2.

R0508 

Application
Riboflavin is suitable as a photopolymerization reagent in PAGE by forming free radicals in aqueous solution in the presence of light. Riboflavin photodecomposes to leucoflavin. No free radicals are formed in the absence of oxygen but traces of oxygen allows for leucoflavin to reoxidize with free-radical generation. The catalysts TEMED or DMAPN are commonly added to speed up the free radical formation. The free radicals will cause acrylamide and bis-acrylamide to polymerize to form a gel matrix which can be used for sieving macromolecules. Riboflavin is commonly used in the stacking gel for non-denaturing PAGE because native proteins can be sensitive to persulfate ions from ammonium persulfate. Another advantage of riboflavin over ammonium persulfate is that it will not start polymerizing until the gel is illuminated.

R4500 

Application
Enzyme cofactor
包装
1 kg in poly drum
500 g in poly drum
5, 25, 100 g in glass bottle
Biochem/physiol Actions
Riboflavin is a key component of the redox cofactors flavin adenine dinucleotide (FAD) and flavin mononucleotide (FMN) that are used by a wide variety of flavoprotein oxidoreductases, dehydrogenase(s), decarboxylase(s) and electron transporters.

95170 

Other Notes
Review: Flavin Coenzymes: At the crossroads of biological redox chemistry1

47861 

General description
用于 Supelco MIP SPE 萃取柱的标准品。欲知更多信息，请索取 Supelco 资料 T407075、T706022

R414995 

Nutritional factor found in milk, eggs, malted barley, liver, kidney, heart, leafy vegetables. Richest natural source is yeast. Minute amounts present in all plant and animal cells. Vitamin (enzyme cofactor).