Drug Groups

approved

Description

A cyclohexylamido analog of penicillanic acid. [PubChem]

Indication

For the treatment of bacterial infections caused by susceptible organisms.

Pharmacology

Cyclacillin, a penicillin, is a cyclohexylamido analog of penicillanic acid. Cyclacillin is more resistant to beta-lactamase hydrolysis than ampicillin, is much better absorbed when given by mouth and, as a result, the levels reached in the blood and in the urine are considerably higher than those obtained with the same dose of ampicillin. Cyclacillin has been replaced by newer penicillin treatments.

Toxicity

Symptoms of overdose include severe diarrhea, nausea and vomiting.

Affected Organisms

Absorption

Moderately absorbed.