物质信息
ID:181754
名称和标识
IUPAC标准名
3-[(3E)-3-(hydroxyimino)-2,3-dihydro-1H-indol-2-ylidene]-2,3-dihydro-1H-indol-2-one
别名
Indirubin-3′-monoximeIndirubin-3′-oxime
IUPAC传统名
indirubin-3'-monoxime
化合物性质
安全信息
德国WGK号
3
个人保护装置
Eyeshields, Gloves, type N95 (US), type P1 (EN143) respirator filter
产品相关信息
Mol. Weight
mol wt 277.28
纯度
≥98% (HPLC)
理化性质
溶解度
H2O: insoluble
DMSO: >10 mg/mL
外观
solid
描述信息
Biochem/physiol Actions
Indirubin-3′-oxime is a cyclin-dependent kinase inhibitor which functions by competing with ATP for binding to the catalytic subunit; exhibits antiproliferative activity leading to G2/M arrest in many cell lines and G1/S arrest in Jurkat cells.
Indirubin-3′-oxime is a cyclin-dependent kinase inhibitor which functions by competing with ATP for binding to the catalytic subunit; exhibits antiproliferative activity leading to G2/M arrest in many cell lines and G1/S arrest in Jurkat cells.
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