Biochem/physiol Actions Indirubin-3′-oxime is a cyclin-dependent kinase inhibitor which functions by competing with ATP for binding to the catalytic subunit; exhibits antiproliferative activity leading to G2/M arrest in many cell lines and G1/S arrest in Jurkat cells.
A potent inhibitor of GSK-3β (IC50=22nM). Also inhibits CDK1 (IC50=180nM) and CDK (IC50=100nM). It reversibly arrests asynchronous HBL-100 cells at G2. It induces apoptosis in the mammary carcinoma cell line MCF-7 (10μM).
A member of the class of biindoles that is indirubin in which the keto group at position 3' has undergone condensation with hydroxylamine to form the corresponding oxime.
参考文献
PubChem文献
数据源提供
• Leclerc, S., et al.: J. Biol. Chem., 276, 251 (2001)
• Damiens, E., et al.: Oncogene, 20, 3786 (2001)
• Marko, D., et al.: Br. J. Cancer, 84, 283 (2001)
