物质信息
ID:181241
名称和标识
IUPAC标准名
{[(2R,3R,4S,5R)-6-[(2S)-2-chloro-1-{[(2S,4R)-1-methyl-4-propylpyrrolidin-2-yl]formamido}propyl]-4,5-dihydroxy-2-(methylsulfanyl)oxan-3-yl]oxy}phosphonic acid
别名
Clindamycin 2-phosphateClindamycin 2-dihydrogen phosphate
IUPAC传统名
[(2R,3R,4S,5R)-6-[(2S)-2-chloro-1-{[(2S,4R)-1-methyl-4-propylpyrrolidin-2-yl]formamido}propyl]-4,5-dihydroxy-2-(methylsulfanyl)oxan-3-yl]oxyphosphonic acid
化合物性质
安全信息
安全公开号
36
德国WGK号
3
个人保护装置
dust mask type N95 (US), Eyeshields, Gloves
RTECS编号
GF2625000
危险公开号
22
保存温度
2-8°C
GHS警示词
Warning
GHS危险声明
H302
欧盟危险性物质标志
有害性 (Xn)GHS危险品标识
急性毒性（口服，皮肤接触，吸入），类别4
皮肤刺激，类别2
眼刺激，类别2
皮肤过敏，类别1
特定目标器官毒性 -一次接触，类别3
描述信息
Biochem/physiol Actions
Spectrum of Activity: Gram positive cocci and taxoplasma. Especially active against anaerobic bacteria.Mode of Action: Inhibits protein synthesis in bacterial by binding the 50s ribosomal subunit.
Clindamycin 2-phosphate is a pharmacological tyrosyl-DNA phosphodiesterase (Tdp1) inhibitor. Clindamycin 2-phosphate can repair DNA topoisomerase I-DNA covalent complexes by hydrolyzing the tyrosyl-DNA bond. It inhibits protein synthesis in bacteria by binding the 50s ribosomal subunit. 2. Spectrum of Activity: Gram positive cocci and taxoplasma. Especially active against anaerobic bacteria.
Other Notes
Antibacterial and antiprotozoal antibiotic of the licosamide class.
Application
Clindamycin 2-phosphate is an aminoglycoside antibiotic that has been used to study the cytoxicity of antibiotics on human cell lines 1, Bacterial protein synthesis and peptide translation, and the inhibition of human Tyrosyl-DNA Phosphodiesterase 2.
Spectrum of Activity: Gram positive cocci and taxoplasma. Especially active against anaerobic bacteria.Mode of Action: Inhibits protein synthesis in bacterial by binding the 50s ribosomal subunit.
Clindamycin 2-phosphate is a pharmacological tyrosyl-DNA phosphodiesterase (Tdp1) inhibitor. Clindamycin 2-phosphate can repair DNA topoisomerase I-DNA covalent complexes by hydrolyzing the tyrosyl-DNA bond. It inhibits protein synthesis in bacteria by binding the 50s ribosomal subunit. 2. Spectrum of Activity: Gram positive cocci and taxoplasma. Especially active against anaerobic bacteria.
Other Notes
Antibacterial and antiprotozoal antibiotic of the licosamide class.
Application
Clindamycin 2-phosphate is an aminoglycoside antibiotic that has been used to study the cytoxicity of antibiotics on human cell lines 1, Bacterial protein synthesis and peptide translation, and the inhibition of human Tyrosyl-DNA Phosphodiesterase 2.
分子图谱
暂无数据
点击上传数据
参考文献
暂无数据
点击上传数据