化合物信息

02158836 

Reversible inhibitor of serine proteases, including chymotrypsin, trypsin, clotting factors XIa and XIIa. Also inhibits some endopeptidase such as protease (Staph. V-8). Does not inhibit papain.

DB04459 

Drug information: experimental

D7910 

Application
Useful in a rapid staining method for identification of macrophages; counts by this method were confirmed by the more complex morphological criteria, by phagocytosis, and by the presence of Fc receptors.1
Other Notes
Effective concentration 5-100 μM.
Quantity
Half-life = 20 min at pH 7.5.
Substrates
Serine protease inhibitor. Active towards a wide range of serine proteases including granzymes. Not active toward β-lactamases.

35913 

Other Notes
Effective concentration 5-100 μM.
Inhibitor of serine proteases1; Inhibition of porcine pancreatic elastase2
Quantity
Half-life = 20 min at pH 7.5.
Substrates
Serine protease inhibitor. Active towards a wide range of serine proteases including granzymes. Not active toward β-lactamases.
Biochem/physiol Actions
Inhibitor of serine proteases1 and porcine pancreatic elastase2. Treatment of proteasomes leads to rapid inactivation of chymotrypsin-like activity and slower inactivation of other proteases.3