Research Area: Cancer
Biological Activity:
Isoliquiritigenin (GU 17) is a strong nod gene- and glyceollin resistance-inducing flavonoid from soybean root exudate. Isoliquiritigenin (GU 17) is a licorice chalcone, a type of flavonoid. Isoliquiritigenin (GU 17)  is currently under experimentation phase testing for use as a cancer treatment as well as an aide for cocaine addiction. Isoliquiritigenin (GU 17)  is a sirtuin-activating compound. The ability of isoliquiritigenin (GU 17) to suppress metastasis was examined in a pulmonary metastasis model of mouse renal cell carcinoma. Isoliquiritigenin (GU 17) significantly reduced pulmonary metastasis, without any weight loss or leukocytopenia. Isoliquiritigenin (GU 17) suppressed in vitro proliferation of carcinoma cells, potentiated nitric oxide production by lipopolysaccharide-stimulated macrophages, and facilitated cytotoxicity of splenic lymphocytes in vitro. [1][2]