化合物信息

DB03285 

Drug information: experimental

S2404 

Research Area: Cancer
Biological Activity:
Isoliquiritigenin (GU 17) is a strong nod gene- and glyceollin resistance-inducing flavonoid from soybean root exudate. Isoliquiritigenin (GU 17) is a licorice chalcone, a type of flavonoid. Isoliquiritigenin (GU 17)  is currently under experimentation phase testing for use as a cancer treatment as well as an aide for cocaine addiction. Isoliquiritigenin (GU 17)  is a sirtuin-activating compound. The ability of isoliquiritigenin (GU 17) to suppress metastasis was examined in a pulmonary metastasis model of mouse renal cell carcinoma. Isoliquiritigenin (GU 17) significantly reduced pulmonary metastasis, without any weight loss or leukocytopenia. Isoliquiritigenin (GU 17) suppressed in vitro proliferation of carcinoma cells, potentiated nitric oxide production by lipopolysaccharide-stimulated macrophages, and facilitated cytotoxicity of splenic lymphocytes in vitro. [1][2]

I3766 

Biochem/physiol Actions
Soluble guanylyl cyclase activator. Possesses antitumor activity.
Caution
Photosensitive, hygroscopic
Other Notes
Tandem Mass Spectrometry data independently generated by Scripps Center for Metabolomics is available to view or download in PDF. I3766.pdf Tested metabolites are featured on Scripps Center for Metabolomics METLIN Metabolite Database. To learn more, visit sigma.com/metlin.

I820850 

Isoliquiritigenin (ISL) is a flavonoid found in licorice root and several other plants that displays antioxidant, anti-inflammatory, and antitumor activities as well as hepatoprotection against steatosis-induced oxidative stress. ISL induces quinone reduc

CHEBI:310312 

A member of the class of chalcones that is trans-chalcone hydroxylated at C-2', -4 and -4'.