物质信息
ID:715064
名称和标识
IUPAC标准名
1-[chloro(4-methoxyphenyl)benzyl]-4-methoxybenzene
IUPAC传统名
1-[chloro(4-methoxyphenyl)benzyl]-4-methoxybenzene
别名
DMT4,4'-Dimethoxytriphenylmethyl chloride4,4'-Dimethoxytrityl chloride4,4'-二甲氧基三苯基氯甲烷
化合物性质
安全信息
欧盟危险性物质标志
刺激性 (Xi)保存注意事项
Moisture Sensitive
GHS危险品标识
急性毒性（口服，皮肤接触，吸入），类别4
皮肤刺激，类别2
眼刺激，类别2
皮肤过敏，类别1
特定目标器官毒性 -一次接触，类别3
GHS警示性声明
P261-P305+P351+P338-P302+P352-P321-P405-P501A
GHS危险声明
H315-H319-H335
安全公开号
26-37
危险公开号
36/37/38
TSCA收录
否
理化性质
熔点
121-127°C
产品相关信息
纯度
98%
描述信息
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分子图谱
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参考文献
• For selective protection and deprotection procedures for SH and OH groups in nucleoside derivatives, see: Synlett, 83 (1993).
• Selective cleavage in acid-sensitive nucleosides and nucleotides without competing N-glycosyl cleavage has also been accomplished by the use of 1,1,1,3,3,3-Hexafluoro-2-propanol, A12747: Tetrahedron Lett., 36, 7833 (1995). For deprotection with montmorillonite K 10 clay, see: J. Org. Chem., 61, 9026 (1996).
• Reagent for protection of alcohols, compare Chlorotriphenylmethane, A11799 as their dimethoxytrityl (Dmt) ethers. Mono-, di- and trimethoxytrityl chlorides form ethers of increasing acid-lability, each MeO group increasing the rate of cleavage by ca x10: J. Am. Chem. Soc., 84, 430 (1962); 85, 3821 (1963). The group is introduced e.g. by reaction with the alcohol in pyridine solution. For use of DMAP as catalyst, see: J. Am. Chem. Soc., 104, 1316 (1982), or of silver nitrate: Can. J. Chem., 60, 1106 (1982).
• In a comparison with Mmt for N-protection during solid-phase peptide synthesis, the N-Mmt group was found to survive intact whereas N-Dmt derivatives decomposed slowly in protic solvents: Tetrahedron. Lett., 39, 1733 (1998).