CAS 40615-36-9|4,4'-Dimethoxytrityl chloride|1-[chloro(4-methoxyphenyl)benzyl]-4-methoxybenzene|1-[chloro(4-methoxyphenyl)benzyl]-4-methoxybenzene|4,4′-二甲氧基氯化三苯甲烷|DMT-Cl|4,4′-Dimethoxytr...

基本信息

化学结构

分子式

C₂₁H₁₉ClO₂

分子量

338.82736

精确质量

338.10735753

电荷

InChI

InChI=1S/C21H19ClO2/c1-23-19-12-8-17(9-13-19)21(22,16-6-4-3-5-7-16)18-10-14-20(24-2)15-11-18/h3-15H,1-2H3

InChIKey

JBWYRBLDOOOJEU-UHFFFAOYSA-N

Canonic Smiles

COc1ccc(cc1)C(c1ccc(cc1)OC)(c1ccccc1)Cl

Isomeric Smiles

C(c1ccc(cc1)OC)(c1ccc(cc1)OC)(c1ccccc1)Cl

计算属性

JChem

质子受体

质子供体

LogD (pH = 5.5)

5.6776276

LogD (pH = 7.4)

5.6776276

Log P

5.6776276

摩尔折射率

99.2889

极化性

38.210403

极化表面积

18.46

可自由旋转的化学键

里宾斯基五规则

false

数据来源

名称和标识

别名

4,4'-Dimethoxytrityl chlorideDMT-Cl4,4′-二甲氧基氯化三苯甲烷4,4′-Dimethoxytrityl chloride4,4′-Dimethoxytriphenylmethyl chlorideDMT4,4′-Dimethoxytrityl chlorideChloro-4,4′-dimethoxytriphenylmethane4,4′-二甲氧基氯化三苯甲烷4,4′-二甲氧基三苯甲基氯氯-4,4′-二甲氧基三苯基甲烷4,4'-Dimethoxytriphenylmethyl chloride4,4'-Dimethoxytrityl chloride4,4'-二甲氧基三苯基氯甲烷

IUPAC标准名

1-[chloro(4-methoxyphenyl)benzyl]-4-methoxybenzene

IUPAC传统名

1-[chloro(4-methoxyphenyl)benzyl]-4-methoxybenzene

名称和标识

数据登录号

CAS号

Beilstein号

EC号

MDL号

PubChem SID

2484651116203393524864217

PubChem CID

96831

数据登录号

化合物性质

理化性质

熔点

119-123 °C(lit.)

123-125 °C

121-127°C

药理学性质

相关基因信息

human ... HTR2A(3356), HTR2B(3357), HTR2C(3358)rat ... Htr1a(24473), Htr2a(29595)

化合物性质

分子相关蛋白质

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分子图谱

暂无数据

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描述信息

MP Biomedicals

02150925

Protecting reagent for oligonucleotide synthesis.

Sigma Aldrich

100013

包装
5, 25 g in glass bottle
Application
用于核苷1,2,3和核苷酸4的羟基保护基团。

38827

Other Notes
有用的保护基团试剂1,2,3；移除4
包装
10, 50 g in glass bottle

描述信息

参考文献

PubChem文献

数据源提供

• For selective protection and deprotection procedures for SH and OH groups in nucleoside derivatives, see: Synlett, 83 (1993).

• Selective cleavage in acid-sensitive nucleosides and nucleotides without competing N-glycosyl cleavage has also been accomplished by the use of 1,1,1,3,3,3-Hexafluoro-2-propanol, A12747: Tetrahedron Lett., 36, 7833 (1995). For deprotection with montmorillonite K 10 clay, see: J. Org. Chem., 61, 9026 (1996).

• Reagent for protection of alcohols, compare Chlorotriphenylmethane, A11799 as their dimethoxytrityl (Dmt) ethers. Mono-, di- and trimethoxytrityl chlorides form ethers of increasing acid-lability, each MeO group increasing the rate of cleavage by ca x10: J. Am. Chem. Soc., 84, 430 (1962); 85, 3821 (1963). The group is introduced e.g. by reaction with the alcohol in pyridine solution. For use of DMAP as catalyst, see: J. Am. Chem. Soc., 104, 1316 (1982), or of silver nitrate: Can. J. Chem., 60, 1106 (1982).

• In a comparison with Mmt for N-protection during solid-phase peptide synthesis, the N-Mmt group was found to survive intact whereas N-Dmt derivatives decomposed slowly in protic solvents: Tetrahedron. Lett., 39, 1733 (1998).

参考文献

生物活性

PubChem BioAssay

生物活性