物质信息
ID:289
名称和标识
IUPAC标准名
4-{bis[4-(dimethylamino)phenyl]methylidene}-N,N-dimethylcyclohexa-2,5-dien-1-iminium chloride
IUPAC传统名
gentian violet chloride
别名
Gentian VioletCrystal Violet
商标名
OxyozylPaper Blue RVermicidViolet 6BNHexamethylpararosaniline chlorideHidaco Brilliant Crystal VioletMethyl Violet 10BKMethyl violetMethylrosaniline chlorideOxiuranCrystal Violet chloride saltGenapaxGentiavermGentiolettenHectograph Violet SRHexamethyl VioletBasic Violet 3Crystal Violet 5BOCrystal Violet AOCrystal Violet BPCCrystal Violet FNCrystal Violet baseMethyl Violet 5BOMethyl Violet 6BPlastoresin Violet 5BOViolet XXIIIAizen Crystal VioletAniline VioletGvsHecto Violet RMethyl Violet 10BMethyl Violet 10BNSMethyl Violet 10BOMethyl Violet 5BNOBasic Violet-3Brilliant Violet 5BCrystal Violet AONCrystal Violet Extra Pure APNXCrystal Violet HL2Crystal Violet OMitsui Crystal VioletOxycolorPyoktanincrystal violet for microscopygentian violet grmethylrosanilinium chlorideGV-ElevenGentersalGenticidHidaco crystal VioletMethyl Violet 10BDMethyl Violet 10BNCrystal Violet 6BCrystal Violet 6BOCrystal Violet BPCrystal Violet Extra PureCrystal Violet Pure DSCCrystal Violet USPAizen Crystal Violet Extra PureAniline Violet pyoktanineAtmonilBasic Violet BNCalcozine Violet CCrystal Violet 10Bgention violet alchoholic staining solutionAdergonMeroxyl-WanderMeroxylan-WanderVianinViocidViolet 5BOViolet CPCalcozine Violet 6BNCrystal Violet Extra Pure APNCrystal Violet Pure DSC BrilliantCrystal Violet SSCrystal Violet TechnicalCrystal Violet chlorideAverminAxurisBadilBismuth VioletC.I. Basic Violet 3
化合物性质
理化性质
疏水性(logP)
3.18
溶解度
4 mg/mL
描述信息
Drug Groups
approved
Description
A dye that is a mixture of violet rosanilinis with antibacterial, antifungal, and anthelmintic properties. [PubChem]
Indication
For the treatment of bacterial and fungal infections inside the mouth (thrush) and skin, also for the prevention of transmission of Chagas' disease (as a blood additive).
Pharmacology
Gentian violet is a mutagen, a mitotic poison, and a clastogen. Gentian violet has been used in medicine for almost 100 years: as an antiseptic for external use, as a topical antibiotic, as a topical antifungal agent, as an antihelminthic agent by oral administration, and more recently, as a blood additive to prevent transmission of Chagas' disease. It is thought to work by binding to the DNA of target organisms and causing disruption, mutation or inhibition of DNA replication.
Toxicity
LD50=420 mg/kg (rat, oral). Oral administration can cause gastrointestinal irritation, and intravenous injection can cause depression in the white blood cell count.
Affected Organisms
Yeast and other fungi
Bacteria and protozoa
Biotransformation
Primarily hepatic, mostly demethylation
External Links
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