化合物信息

DB01024 

S2487 

Research Area: Immunology
Biological Activity:
Mycophenolic acid (mycophenolate) is an immunosuppressant agent used to prevent rejection in organ transplantation. Mycophenolic acid (mycophenolate) is derived from the fungus Penicillium stoloniferum. Mycophenolate mofetil is metabolised in the liver to the active moiety mycophenolic acid. Mycophenolic acid (mycophenolate) inhibits inosine monophosphate dehydrogenase, the enzyme that controls the rate of synthesis of guanine monophosphate in the de novo pathway of purine synthesis used in the proliferation of B and T lymphocytes. [1] Mycophenolic acid (mycophenolate) is potent and can be used in place of the older anti-proliferative azathioprine. Mycophenolic acid (mycophenolate) is usually used as part of a three-compound regimen of immunosuppressants, also including a calcineurin inhibitor (ciclosporin or tacrolimus) and prednisolone. [2]

02194172 

From Penicillium brevi compactum
Purity: 98%

Mycophenolic_acid 

M3536 

Application
Recommended for use as a selection agent at 25 μg/ml.
Used to select animal cells expressing the Escherichia coli gene for xanthine-guanine phosphosribosyl transferase.
Biochem/physiol Actions
Immunosuppressive agent. Suppresses cytokine-induced nitric oxide production.
Immunosuppressive agent. Used to inhibit early stage biosynthesis of purine nucleotides. Used as a specific inhibitor of inosine 5′-monophosphate (IMP) dehydrogenase (IMPDH) and inducer of IMP dehydrogenase gene expression.
Protocols & Applications
Antibiotic Selector for application, solubility, solution stability, working concentration, and mode of action information

M5255 

Application
Used to select animal cells expressing the Escherichia coli gene for xanthine-guanine phosphosribosyl transferase.
Biochem/physiol Actions
Immunosuppressive agent. Suppresses cytokine-induced nitric oxide production.
Protocols & Applications
Antibiotic Selector for application, solubility, solution stability, working concentration, and mode of action information

70018 

Application
Used to select animal cells expressing the Escherichia coli gene for xanthine-guanine phosphosribosyl transferase.
Biochem/physiol Actions
Immunosuppressive agent. Suppresses cytokine-induced nitric oxide production.
Other Notes
Antibiotic substance. Inhibits IMP dehydrogenase1

M831500 

An antibiotic produced by Penicillium brevi-compactum, P. Stoloniferum and related spp. A selective inhibitor of lymphocyte proliferation by blocking inosine monophosphate dehydrogenase, an enzyme involved in the de novo synthesis of purine nucleotides.

CHEBI:168396 

A member of the class of 2-benzofurans that is 2-benzofuran-1(3H)-one which is substituted at positions 4, 5, 6, and 7 by methyl, methoxy, (2E)-5-carboxy-3-methylpent-2-en-1-yl, and hydroxy groups, respectively. It is an antibiotic produced by Penicillium brevi-compactum, P. stoloniferum, P. echinulatum and related species. An immunosuppressant, it is widely used (partiularly as its sodium salt and as the 2-(morpholin-4-yl)ethyl ester prodrug, mycophenolate mofetil) to prevent tissue rejection following organ transplants and for the treatment of certain autoimmune diseases.