化合物信息

S2509 

Research Area: Neurological Disease
Biological Activity:
Sotalol (Betapace) is a non-selective beta blocker and a potassium channel blocker with an IC50 of 43 µM. Sotalol definitely distinctly located binding site to interfere with K+ permeation; both enantiomers associated with a rate close to 5 ? 105 /mol/ sec with the open pore thereby flicker-blocking cardiac K(ATP) channels. [1][2]

02193715 

Hydrochloride
A potent β-adrenergic antagonist.

S0278 

Biochem/physiol Actions
Potent β-adrenoceptor antagonist; class III antiarrhythmic; prolongs the action potential and increases the refractory period.

CHEBI:9207 

A hydrochloride salt that is the monohydrochloride of sotalol. It has both beta-adrenoreceptor blocking (Vaughan Williams Class II) and cardiac action potential duration prolongation (Vaughan Williams Class III) antiarrhythmic properties. It is used (usually as the hydrochloride salt) for the management of ventricular and supraventricular arrhythmias.