化合物信息

S2490 

Research Area: Neurological Disease
Biological Activity:
Neostigmine bromide(Prostigmin) is a reversible acetylcholinesterase inhibitor and a parasympatho-mimetic. By interfering with the breakdown of acetylcholine, neostigmine indirectly stimulates both nicotinic and muscarinic receptors. It binds to the anionic site of cholinesterase. The drug blocks the active site of acetylcholinesterase so the enzyme can no longer break down the acetylcholine molecules before they reach the postsynaptic membrane receptors. This allows for the threshold to be reached so a new impulse can be triggered in the next neuron. In myasthenia gravis there are too few acetylcholine receptors so with the acetylcholinesterase blocked, acetylcholine can bind to the few receptors and trigger a muscular contraction. [1]References on Neostigmine bromide (Prostigmin)[1] http://en.wikipedia.org/wiki/Neostigmine, ,

02153553 

Inhibitor of acetylchloinesterase

05206456 

MP Biomedicals Rare Chemical collection

N2001 

Biochem/physiol Actions
Reversible inhibitor of acetylcholinesterase that is similar to eserine, but does not cross the blood-brain barrier.

N390010 

Cholinergic; miotic; antidote (curare).