化合物信息

S2458 

Research Area: Cardiovascular Disease
Biological Activity:
Clonidine hydrochloride(Catapres) is a direct-acting α2 adrenergic agonist with an ED50 of 0.02±0.01 mg/kg. [1] It treats high blood pressure by stimulating α2 receptors in the brain, which decreases cardiac output and peripheral vascular resistance, lowering blood pressure. It has specificity towards the presynaptic α2 receptors in the vasomotor center in the brainstem. This binding decreases presynaptic calcium levels, and inhibits the release of norepinephrine (NE). The net effect is a decrease in sympathetic tone. [2]

02190175 

Hydrochloride
(2-(2,6-Dichloroaniline)-2-imidazoline)
Antihypertensive, α₂ -adrenoceptor agonist and imidazoline receptor ligand.

C7897 

Biochem/physiol Actions
α2-adrenoceptor agonist; I1 imidazoline binding site ligand.

27545 

Other Notes
Interacts with α-adrenergic receptors1

C587130 

Labelled Clonidine. α2-Adrenergic agonist. Antihypertensive; analgesic for neuropathic pain.