化合物信息

S2539 

Research Area: Infection
Biological Activity:
Lomefloxacin hydrochloride (Maxaquin) is a hydrochloride salt of lomefloxacin and is a fluoroquinolone antibiotic.Lomefloxacin hydrochloride (Maxaquin) is used to treat bacterial infections including bronchitis and urinary tract infections. Lomefloxacin hydrochloride (Maxaquin) is also used to prevent urinary tract infections prior to surgery. [1]

L2906 

Application
Lomefloxacin is a fluoroquinolone antibiotic that is commonly used to treat bacterial infections, including bronchitis and urinary tract infections. It is used as a pre-operative prophylactic to prevent urinary tract infection caused by S. pneumoniae, H. influenzae, S. aureus, P. aeruginosa, E. cloacae, P. mirabilis, C. civersus, S. asprphyticus, E. coli, and K. pneumoniae. It is used to induce genomic instability in mice1 and modification of the kinetics of growth of Gram-negative bacteria2.
Biochem/physiol Actions
Lomefloxacin inhibits bacterial DNA gyrase (topoisomerase II) and topoisomerase IV.
Lomefloxacin is a bactericidal fluoroquinolone agent that is active against gram-negative and gram-positive organisms. Lomefloxacin inhibits bacterial DNA gyrase (topoisomerase II) and topoisomerase IV, which are needed for the transcription and replication of bacterial DNA. DNA gyrase is thought to be the primary quinolone target for gram-negative bacteria. Topoisomerase IV is thought to be the primary target in gram-positive organisms. The inhibition of the topoisomerases results in strand breakage of the bacterial chromosome, supercoiling, and resealing. Therefore, DNA replication and transcription is inhibited .

L469415 

Lomefloxacin is a fluorinated quinolone antibacterial. Lomefloxacin is a DNA gyrase antagonist.