化合物信息

DB08468 

Drug information: experimental

S1327 

Research Area: Cancer
Biological Activity:
Ellagic acid is a polyphenol antioxidant found in numerous fruits and vegetables. Ellagic acid also has antiproliferative property. Ellagic acid may slow the growth of some tumors caused by certain carcinogens. Ellagic acid can inhibit the two topoisomerases (IC50 was 0.6 and 0.7 μg/ml for topo I and topo II). [1]References on Ellagic acid[1] Nutrition and Cancer , 1995, 23(2)

Ellagic_acid 

E2250 

Biochem/physiol Actions
Commonly occurring plant polyphenol, inhibitor of glutathione S-transferase.1 Used for the assay of factor XIIa in plasma.2 Contact activation in blood coagulation.3
A naturally occurring plant phenol that is a potent antioxidant presumably by acting as a scavenger of oxygen species produced by hydrogen peroxide treatment, and as a protector of the DNA double helix from alkylating agent injury. It therefore has anti-mutagenic and anti-carcinogenic properties. Also reported to inhibit topoisomerases I and II and gyrase.

45140 

Biochem/physiol Actions
Commonly occurring plant polyphenol, inhibitor of glutathione S-transferase.1 Used for the assay of factor XIIa in plasma.2 Contact activation in blood coagulation.3

14668 

Biochem/physiol Actions
Commonly occurring plant polyphenol, inhibitor of glutathione S-transferase.1 Used for the assay of factor XIIa in plasma.2 Contact activation in blood coagulation.3