CAS 57574-09-1|CAS 30272-08-3|Amineptine|N-(6-carboxyhexyl)tricyclo[9.4.0.0^{3,8}]pentadeca-1(11),3(8),4,6,12,14-hexaen-2-aminium chloride|Amineptine hydrochloride|N-(6-carboxyhexyl)tricyclo[9.4.0.0...

基本信息

化学结构

分子式

C₂₂H₂₈ClNO₂

分子量

373.91622

精确质量

373.18085682

电荷

0

InChI

InChI=1S/C22H27NO2.ClH/c24-21(25)13-3-1-2-8-16-23-22-19-11-6-4-9-17(19)14-15-18-10-5-7-12-20(18)22;/h4-7,9-12,22-23H,1-3,8,13-16H2,(H,24,25);1H

InChIKey

VDPUXONTAVMIKZ-UHFFFAOYSA-N

Canonic Smiles

OC(=O)CCCCCC[NH2+]C1c2ccccc2CCc2c1cccc2.[Cl-]

Isomeric Smiles

[Cl-].OC(=O)CCCCCC[NH2+]C1c2c(CCc3c1cccc3)cccc2

计算属性

JChem

LogD (pH = 7.4)

2.74

LogD (pH = 5.5)

2.72

Log P

2.74

可自由旋转的化学键

8

质子供体

2

质子受体

2

里宾斯基五规则

true

Acid pKa

4.41

极化表面积

53.91

极化性

39.99

摩尔折射率

112.63

LOG S

-4.69

数据来源

学术数据

数据来源

名称和标识

别名

AmineptineAmineptine hydrochloride7-(10,11-dihydro-5H-dibenzo[a,d]cyclohepten-5-ylamino)heptanoic acid hydrochlorideamineptine hydrochloride

IUPAC标准名

N-(6-carboxyhexyl)tricyclo[9.4.0.0^{3,8}]pentadeca-1(11),3(8),4,6,12,14-hexaen-2-aminium chloride N-(6-carboxyhexyl)tricyclo[9.4.0.0³,⁸]pentadeca-1(15),3,5,7,11,13-hexaen-2-aminium chloride

IUPAC传统名

N-(6-carboxyhexyl)tricyclo[9.4.0.0^{3,8}]pentadeca-1(11),3(8),4,6,12,14-hexaen-2-aminium chloride N-(6-carboxyhexyl)tricyclo[9.4.0.0^{3,8}]pentadeca-1(15),3,5,7,11,13-hexaen-2-aminium chloride

商标名

SurvectorManeon

名称和标识

数据登录号

PubChem SID

4650901216096781249742801

CAS号

PubChem CID

ACToR数据库

SureChEMBL数据库

Beilstein号

CHEBI ID

CHEMBL

数据登录号

化合物性质

暂无数据

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分子相关蛋白质

暂无数据

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分子图谱

暂无数据

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描述信息

DrugBank

DB04836

Drug Groups

illicit; withdrawn

Description

The Food and Drug Administration suspended the marketing authorisation for Survector in 1999 and France withdrew it from the market, however several developing countries continued to produce it up until 2005.

Indication

For the treatment of depression.

Pharmacology

Amineptine is an atypical tricyclic antidepressant.

Affected Organisms

Humans and other mammals

Biotransformation

Hepatic.

Half Life

48 minutes for the parent drug and 2.5 hours for the metabolites.

References

• Vaugeois JM, Corera AT, Deslandes A, Costentin J: Although chemically related to amineptine, the antidepressant tianeptine is not a dopamine uptake inhibitor. Pharmacol Biochem Behav. 1999 Jun;63(2):285-90. [Pubmed]

• Grupper C: [New iatrogenic acne: acne caused by amineptin (Survector)] Ann Dermatol Venereol. 1988;115(11):1174-6. [Pubmed]

• Thioly-Bensoussan D, Charpentier A, Triller R, Thioly F, Blanchet P, Tricoire N, Noury JY, Grupper C: [Iatrogenic acne caused by amineptin (Survector). Apropos of 8 cases] Ann Dermatol Venereol. 1988;115(11):1177-80. [Pubmed]

• Vexiau P, Gourmel B, Husson C, Castot A, Rybojad M, Julien R, Fiet J, Puissant A, Cathelineau G: [Severe lesions of acne type induced by chronic amineptin poisoning: apropos of 6 cases] Ann Dermatol Venereol. 1988;115(11):1180-2. [Pubmed]

• Teillac D, Weber MJ, Lowenstein W, de Prost Y: [Acne caused by Survector] Ann Dermatol Venereol. 1988;115(11):1183-4. [Pubmed]

External Links

• [Wikipedia]

描述信息

参考文献

PubChem文献

数据源提供

• Vexiau P, Gourmel B, Husson C, Castot A, Rybojad M, Julien R, Fiet J, Puissant A, Cathelineau G: [Severe lesions of acne type induced by chronic amineptin poisoning: apropos of 6 cases] Ann Dermatol Venereol. 1988;115(11):1180-2. Pubmed

• Vaugeois JM, Corera AT, Deslandes A, Costentin J: Although chemically related to amineptine, the antidepressant tianeptine is not a dopamine uptake inhibitor. Pharmacol Biochem Behav. 1999 Jun;63(2):285-90. Pubmed

• Thioly-Bensoussan D, Charpentier A, Triller R, Thioly F, Blanchet P, Tricoire N, Noury JY, Grupper C: [Iatrogenic acne caused by amineptin (Survector). Apropos of 8 cases] Ann Dermatol Venereol. 1988;115(11):1177-80. Pubmed

• Grupper C: [New iatrogenic acne: acne caused by amineptin (Survector)] Ann Dermatol Venereol. 1988;115(11):1174-6. Pubmed

• Teillac D, Weber MJ, Lowenstein W, de Prost Y: [Acne caused by Survector] Ann Dermatol Venereol. 1988;115(11):1183-4. Pubmed

参考文献

生物活性

PubChem BioAssay

生物活性

化合物信息

ID:4380