化合物信息

DB01852 

Drug information: experimental

S2314 

Research Area: Neurological Disease
Biological Activity:
Kaempferol is a natural flavonol, a type of flavonoid, that has been isolated from plant sources. It is what gives the flowers of Acacia decurrens and Acacia longifolia their color. The compound has antidepressant properties. The enzyme kaempferol 4’-O-methyltransferase uses S-adenosyl methionine and kaempferol to produce S-adenosylhomocysteine and kaempferide. [1]

02155143 

(3,5,7-Trihydroxy-2-[4-hydroxy- phenyl]-4H-1-benzopyran-4-one; 3,4',5,7-Tetrahydroxyflavone) Yellow crystals.

05201074 

MP Biomedicals Rare Chemical collection

Kaempferol 

K0133 

Application
Chromogenic reagent for antimony in the low ppm range2 and for gallium and indium in the sub-ppm range.3
Biochem/physiol Actions
A flavonol shown to revert the transformed phenotype of phorbol ester-treated mouse fibroblasts or v-H-ras-transformed NIH 3T3 cells. Induces significant nuclear DNA degradation concurrent with lipid peroxidation.4 Inhibits topoisomerase I catalyzed DNA religation.5 Kaempferol may also inhibit the activity of fatty acid synthase.
Potent inhibitor of osteoclastic bone resorption. The effect is believed to be attributable to both the antioxidant and estrogenic activities of kaempferol.1

96353 

Application
Chromogenic reagent for antimony in the low ppm range2 and for gallium and indium in the sub-ppm range.3
Biochem/physiol Actions
Potent inhibitor of osteoclastic bone resorption. The effect is believed to be attributable to both the antioxidant and estrogenic activities of kaempferol.1

60010 

Application
Chromogenic reagent for antimony in the low ppm range2 and for gallium and indium in the sub-ppm range.3
Biochem/physiol Actions
Potent inhibitor of osteoclastic bone resorption. The effect is believed to be attributable to both the antioxidant and estrogenic activities of kaempferol.1
Other Notes
Tandem Mass Spectrometry data independently generated by Scripps Center for Metabolomics is available to view or download in PDF. 60010.pdf Tested metabolites are featured on Scripps Center for Metabolomics METLIN Metabolite Database. To learn more, visit sigma.com/metlin.

K100000 

Kaempferol is a plant flavonoid which play a beneficial role in human health promotion.