化合物信息

Drug Groups

approved

Description

Quinupristin/dalfopristin is a combination of two antibiotics used to treat infections by staphylococci and by vancomycin-resistant Enterococcus faecium. Dalfopristin inhibits the early phase of protein synthesis in the bacterial ribosome and quinupristin inhibits the late phase of protein synthesis. The combination of the two components acts synergistically and is more effective in vitro than each component alone.

Indication

For the treatment of bacterial infections (usually in combination with dalfopristin).

Pharmacology

Quinupristin is a streptogramin antibiotic, derived from pristinamycin I. By inhibiting the bacterial ribosomal subunits, protein synthesis is inhibited thus leading to eventual bacterial cell death or stasis.

Affected Organisms

Biotransformation

Quinupristin is converted to two conjugated active major metabolites, one with
glutathione and one with cysteine.

Half Life

3.1 hours

Protein Binding

Moderate.

References

External Links