Substance
ID:73895
Names and Identifiers
IUPAC name
[3-(2-chloro-10H-phenothiazin-10-yl)propyl]dimethylamine hydrochloride
IUPAC Traditional name
chlorpromazine hydrochloride
Synonyms
Chlorpromazine hydrochloride SonazineChloractilPromacidKlorpromex
Registration numbers
CAS Number
Properties
Safety Information
Storage Condition
-20°C
Product Information
Salt Data
hydrochloride
Molecule Details
Research Area: Neurological Disease
Biological Activity:
Chlorpromazine (Sonazine) is a dopamine and potassium channel inhibitor with IC50 of 6.1 and 16 µM for nward-rectifying K+ currents and time-independent outward currents.In inhibits prolactin release inhibitory factor, thus stimulating the release of prolactin. The turnover of dopamine in the brain is also increased. [1] Chlorpromazine blocks a variety of K+ channels in heart muscle cells. Inasmuch as the potency of inhibition is less than the previously reported use-dependent block of Na+ channels, the cardiovascular adverse effects of chlorpromazine are probably caused mainly by the latter effect. [2]
Biological Activity:
Chlorpromazine (Sonazine) is a dopamine and potassium channel inhibitor with IC50 of 6.1 and 16 µM for nward-rectifying K+ currents and time-independent outward currents.In inhibits prolactin release inhibitory factor, thus stimulating the release of prolactin. The turnover of dopamine in the brain is also increased. [1] Chlorpromazine blocks a variety of K+ channels in heart muscle cells. Inasmuch as the potency of inhibition is less than the previously reported use-dependent block of Na+ channels, the cardiovascular adverse effects of chlorpromazine are probably caused mainly by the latter effect. [2]
Molecular Spectra
No Data Available
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References
• http://en.wikipedia.org/wiki/Chlorpromazine