Substance
ID:714795
Names and Identifiers
IUPAC Traditional name
phenylhydrazine
IUPAC name
phenylhydrazine
Synonyms
Phenylhydrazine苯肼
Registration numbers
CAS Number
EC Number
Beilstein Number
MDL Number
Merck Index
Properties
Physical Property
Boiling Point
238-241°C
Density
1.099
Melting Point
18-20°C
Solubility
Soluble in dilute acids
Refractive Index
1.6065
Flash Point
88°C(190°F)
Safety Information
GHS Pictograms
Acute toxicity (oral, dermal, inhalation), categories 1,2,3
Hazardous to the aquatic environment
Acute hazard, category1
Chronic hazard, categories 1,2
Respiratory sensitization, category 1
Germ cell mutagenicity, categories 1A,1B,2
Carcinogenicity, categories 1A,1B,2
Reproductive toxicity, categories 1A,1B,2
Specific Target Organ Toxicity – Single exposure, categories 1,2
Specific Target Organ Toxicity – Repeated exposure, categories 1,2
Aspiration Hazard, category 1
European Hazard Symbols
Toxic (T)
Nature polluting (N)Packing Group
II
RTECS
MV8925000
TSCA Listed
是
GHS Precautionary statements
P210-P301+P310-P305+P351+P338-P361-P405-P501A
Storage Warning
Air & Light Sensitive
Hazard Class
6.1
GHS Hazard statements
H301-H311-H331-H315-H319-H317-H350-H372-H341-H400-H227
UN Number
UN2572
Risk Statements
45-23/24/25-36/38-43-48/23/24/25-68-50
Safety Statements
53-45-61
Product Information
Purity
97%
Molecule Details
No Data Available
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Molecular Spectra
No Data Available
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References
• Methods used for the cleavage of phenylhydrazones include exchange by refluxing with acetone: J. Org. Chem., 40, 3302 (1975), or oxidative cleavage by Fe(NO3)3 on a clay support: Synthesis, 439 (1985).
• Derivatizing agent for the conversion of carbonyl compounds to their phenylhydrazones best known as intermediates in the Fischer indole synthesis, by cyclization under acidic conditions with loss of ammonia. The classical reagent is anhydrous ZnCl2: Org. Synth. Coll., 3, 725 (1976). For reviews, see: Chem. Rev., 63, 373 (1963); 69, 227 (1969); Tetrahedron, 36, 161 (1980); Org. Prep. Proced. Int., 25,609 (1993). Milder cyclization conditions are sometimes effective, e.g.: dilute H2SO4: J. Org. Chem., 59, 3738 (1994); PCl3: J. Chem. Soc., Chem. Commun., 563 (1981); Tetrahedron, 41, 4615 (1985). Cyclohexanone phenylhydrazone gives tetrahydrocarbazole on heating in acetic acid: Org. Synth. Coll., 4, 884 (1963).