Substance
ID:619
Names and Identifiers
IUPAC name
1-[(4-chlorophenyl)(phenyl)methyl]-4-[(3-methylphenyl)methyl]piperazine
Brand Name
AncolanBonadoxinBonineCalmonalDiadrilDramamine IIRavelonSabariBonadettesHistamethineHistametizineMeclicotNeo-IstafeneParachloramineNeo-SuprimelPostafeneSea-LegsTravelonVomisseisAntivertSiguranSubariVomisselsMeclizine HclMeclozineDramamineItinerolMedivertMonamineNavicalmPeremesinSuprimalVeritabAntivert/25BonamineChiclidaHistamethizineHistametizyneMarexAncolonAntivert/50Neo-Suprimal
IUPAC Traditional name
(+-)-meclizine
Synonyms
Meclizine
Properties
Physical Property
Solubility
0.1gm/100ml
Hydrophobicity(logP)
5.8
Molecule Details
Drug Groups
approved
Description
A histamine H1 antagonist used in the treatment of motion sickness, vertigo, and nausea during pregnancy and radiation sickness. [PubChem]
Indication
For the prevention and treatment of nausea, vomiting, or dizziness associated with motion sickness.
Pharmacology
Meclizine, a piperazine-derivative H1-receptor antagonist similar to buclizine, cyclizine, and hydroxyzine, is used as an antivertigo/antiemetic agent. Meclizine is used in the management of nausea, vomiting, and dizziness associated with motion sickness and vertigo in diseases affecting the vestibular apparatus.
Toxicity
Symptoms of overdose include drowsiness and anticholinergic effects. LD50=mg/kg (orally in rat).
Affected Organisms
Humans and other mammals
Biotransformation
Hepatic
Absorption
Well absorbed
Half Life
6 hours
External Links
Molecular Spectra
No Data Available
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References
No Data Available
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