A histamine H1 antagonist used in the treatment of motion sickness, vertigo, and nausea during pregnancy and radiation sickness. [PubChem]
Indication
For the prevention and treatment of nausea, vomiting, or dizziness associated with motion sickness.
Pharmacology
Meclizine, a piperazine-derivative H1-receptor antagonist similar to buclizine, cyclizine, and hydroxyzine, is used as an antivertigo/antiemetic agent. Meclizine is used in the management of nausea, vomiting, and dizziness associated with motion sickness and vertigo in diseases affecting the vestibular apparatus.
Toxicity
Symptoms of overdose include drowsiness and anticholinergic effects. LD50=mg/kg (orally in rat).
