Substance

ID:576

Names and Identifiers
IUPAC name
3',6'-dihydroxy-3H-spiro[2-benzofuran-1,9'-xanthene]-3-one
IUPAC Traditional name
fluorescein
Synonyms
Fluorescein
Brand Name
Acid Yellow 73Fluorescein disodium salt dihydrateUranineEosinFunduscein-25Fluorescein disodium saltFluorescein sodiumFluorescein Sodium saltFluorescein acidFluorescein, Disodium Salt, Fluorescein, disodium saltFluoresciteUranin
Registration numbers
CAS Number
2321-07-5
PubChem CID
16850
PubChem SID
46504703
Properties
Physical Property
Solubility
600 mg/mL (sodium salt)
Hydrophobicity(logP)
3.4
Molecule Details
Drug Groups
approved
Description
A phthalic indicator dye that appears yellow-green in normal tear film and bright green in a more alkaline medium, such as the aqueous humor, and is used therapeutically as a diagnostic aid in corneal injuries and corneal trauma. It has been approved by FDA for use in externally applied drugs and cosmetics. (From Merck Index, 12th ed; American Medical Association Drug Evaluations; 1995, p2275)
Indication
For diagnostic imaging. Primarily indicated in diagnostic fluorescein angiography or angioscopy of the fundus and of the iris vasculature.
Affected Organisms
Humans and other mammals
Absorption
Rapidly distributed
Protein Binding
85%
Elimination
Fluorescein and its metabolites are mainly eliminated via renal excretion.
Distribution
* 0.5 L/kg
Clearance
* renal cl=1.75 mL/min/kg [After IV administration]
* hepatic cl=1.50 mL/min/kg [After IV administration]
References
• Noga EJ, Udomkusonsri P: Fluorescein: a rapid, sensitive, nonlethal method for detecting skin ulceration in fish. Vet Pathol. 2002 Nov;39(6):726-31. [Pubmed]
External Links
• [Wikipedia]
• [RxList]
Molecular Spectra
No Data Available
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References
• Noga EJ, Udomkusonsri P: Fluorescein: a rapid, sensitive, nonlethal method for detecting skin ulceration in fish. Vet Pathol. 2002 Nov;39(6):726-31. Pubmed
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