A phthalic indicator dye that appears yellow-green in normal tear film and bright green in a more alkaline medium, such as the aqueous humor, and is used therapeutically as a diagnostic aid in corneal injuries and corneal trauma. It has been approved by FDA for use in externally applied drugs and cosmetics. (From Merck Index, 12th ed; American Medical Association Drug Evaluations; 1995, p2275)
Indication
For diagnostic imaging. Primarily indicated in diagnostic fluorescein angiography or angioscopy of the fundus and of the iris vasculature.
Affected Organisms
Humans and other mammals
Absorption
Rapidly distributed
Protein Binding
85%
Elimination
Fluorescein and its metabolites are mainly eliminated via renal excretion.
Distribution
* 0.5 L/kg
Clearance
* renal cl=1.75 mL/min/kg [After IV administration] * hepatic cl=1.50 mL/min/kg [After IV administration]
References
•
Noga EJ, Udomkusonsri P: Fluorescein: a rapid, sensitive, nonlethal method for detecting skin ulceration in fish. Vet Pathol. 2002 Nov;39(6):726-31.
[Pubmed]
A fluorescent tracer used for many applications. It is used in ophthalmology as a tool in the diagnosis of corneal abrasions, corneal ulcers and herpetic corneal infections. It can attach to certain biologically active molecules, thus allowing biologists
A xanthene dye that is highly fluorescent, detectable even when present in minute quantities. Used forensically to detect traces of blood, in analytical chemistry as an indicator in silver nitrate titrations and in microscopy.
References
PubChem Literature
From Data Sources
• Noga EJ, Udomkusonsri P: Fluorescein: a rapid, sensitive, nonlethal method for detecting skin ulceration in fish. Vet Pathol. 2002 Nov;39(6):726-31. Pubmed
• Can. Med. Assoc. J., 80, 997 (1996)
• Drees, B.L. et al.: J. Biol. Chem., 271, 32168 (1996)
• Taki, M. et al.: Prot. Eng. Des. Select., 17, 119 (1996)
Irritant (Xi)