Substance
ID:4
Names and Identifiers
IUPAC name
(2S)-2-amino-3-(1H-imidazol-5-yl)propanoic acid
Synonyms
(S)-4-(2-Amino-2-carboxyethyl)imidazoleGlyoxaline-5-alanineL-Histidine(S)-a-Amino-1H-imidazole-4-propanoic acidHistidine(S)-HistidineL-(-)-Histidine(S)-alpha-Amino-1H-imidazole-4-propionic acid
IUPAC Traditional name
L-histidine
Properties
Physical Property
Hydrophobicity(logP)
-3.4
Solubility
Not AvailableSoluble
Molecule Details
Drug Groups
approved; nutraceutical
Description
An essential amino acid that is required for the production of histamine. [PubChem]
Indication
The actions of supplemental L-histidine are entirely unclear. It may have some immunomodulatory as well as antioxidant activity. L-histidine may be indicated for use in some with rheumatoid arthritis. It is not indicated for treatment of anemia or uremia or for lowering serum cholesterol.
Pharmacology
Is found abundantly in hemoglobin; has been used in the treatment of rheumatoid arthritis, allergic diseases, ulcers and anemia. A deficiency can cause poor hearing.
Toxicity
ORL-RAT LD50 > 15000 mg/kg, IPR-RAT LD50 > 8000 mg/kg, ORL-MUS LD50 > 15000 mg/kg, IVN-MUS LD50 > 2000 mg/kg; Mild gastrointestinal side effects.
Affected Organisms
Humans and other mammals
Absorption
Absorbed from the small intestine via an active transport mechanism requiring the presence of sodium.
External Links
Molecular Spectra
No Data Available
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References
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