An essential amino acid that is required for the production of histamine. [PubChem]
Indication
The actions of supplemental L-histidine are entirely unclear. It may have some immunomodulatory as well as antioxidant activity. L-histidine may be indicated for use in some with rheumatoid arthritis. It is not indicated for treatment of anemia or uremia or for lowering serum cholesterol.
Pharmacology
Is found abundantly in hemoglobin; has been used in the treatment of rheumatoid arthritis, allergic diseases, ulcers and anemia. A deficiency can cause poor hearing.
Biochem/physiol Actions 组胺的前体,经组氨酸脱羧酶作用可生成组胺。 包装 1 kg in poly bottle 5 kg in poly drum 5, 10, 25, 100, 500 g in poly bottle 法律信息 ReagentPlus 注册商标 Sigma-Aldrich Co. LLC
Analysis Note This certified reference material (CRM) is produced and certified in accordance with ISO/IEC 17025 and ISO Guide 34. This CRM is traceable to NIST SRM. Biochem/physiol Actions Precursor of histamine by action of histidine decarboxylase. General description Certified content by quantitative NMR incl. uncertainty and expiry are given in the certificate.Download your certificate at: http://www.sigma-aldrich.com. Legal Information TraceCERT is a registered trademark of Sigma-Aldrich Co. LLC
Biochem/physiol Actions Precursor of histamine by action of histidine decarboxylase. Other Notes Amino acid spacing in isotachophoresis on polyacrylamide gels - a critical evaluation1; Prevents circular DNA strand cleavage in a xanthine-xanthine oxidase system2; Growth requirement of various microorganisms3.
L-Histidine is an essential amino acid for human development which the body cannot produce on its own. L-Histidine is one of the 22 proteinogenic amino acids. L-Histidine precursor to histamine (H436500) and a component of carnosine.
References
PubChem Literature
From Data Sources
• Sachs, D.H., et al.: J. Biol. Chem., 246, 6576 (1975)
• Mercer, L.P., et al.: Nutrition, 6, 273 (1975)
• Morgan, W.T., et al.: J. Biol. Chem., 268, 6256 (1975)
• Kopple, J.D. et al.: J. Clin. Invest., 55, 881 (1975)
