Substance
ID:380
Names and Identifiers
Brand Name
CombunoxDihydroxycodeinoneEndocetEndodanEucodalOxanestEubineEukodalPancodineTecodinTekodinOxyNormDiphydroneEndoneThekodinOxyIROxycodeinoneOxycodonSupendolOxyconPercobarbPercodanRoxicodoneSupeudolOxyFASTRemoxyOxiconOxiconeOxikonDinarkonEucodalumEutagenOxycontinThecodinePercolone
IUPAC name
(1S,5R,13R,17S)-17-hydroxy-10-methoxy-4-methyl-12-oxa-4-azapentacyclo[9.6.1.0^{1,13}.0^{5,17}.0^{7,18}]octadeca-7(18),8,10-trien-14-one
Synonyms
DihydrohydroxycondeinoneOxicodona [INN-Spanish]Oxycodone HclDihydrohydroxycodeinoneDihydroneOxycodonum [INN-Latin]oxycodonePTI-821Oxycodone HydrochlorideOxycodone
IUPAC Traditional name
oxycodone
Properties
Physical Property
Hydrophobicity(logP)
0.3
Solubility
100 mg/ml
Molecule Details
Drug Groups
illicit; approved; investigational
Description
Semisynthetic derivative of codeine that acts as a narcotic analgesic more potent and addicting than codeine. [PubChem]
Indication
For the treatment of diarrhoea, pulmonary oedema and for the relief of moderate to moderately severe pain.
Pharmacology
Oxycodone, a semisynthetic opiate agonist derived from the opioid alkaloid, thebaine, is similar to other phenanthrene derivatives such as hydrocodone and morphine. Oxycodone is available in combination with aspirin or acetaminophen to control pain and restless leg and Tourette syndromes.
Toxicity
Symptoms of overdose include respiratory depression, somnolence progressing to stupor or coma, skeletal muscle flaccidity, cold and clammy skin, constricted pupils, bradycardia, hypotension, and death.
Affected Organisms
Humans and other mammals
Biotransformation
Hepatic
Absorption
Well absorbed with an oral bioavailability of 60% to 87%
Half Life
4.5 hours
Protein Binding
45%
Elimination
Oxycodone and its metabolites are excreted primarily via the kidney.
Distribution
* 2.6 L/kg
Clearance
* 0.8 L/min [adults]
References
•
Ordonez Gallego A, Gonzalez Baron M, Espinosa Arranz E: Oxycodone: a pharmacological and clinical review. Clin Transl Oncol. 2007 May;9(5):298-307.
[Pubmed]
•
Riley J, Eisenberg E, Muller-Schwefe G, Drewes AM, Arendt-Nielsen L: Oxycodone: a review of its use in the management of pain. Curr Med Res Opin. 2008 Jan;24(1):175-92.
[Pubmed]
External Links
Molecular Spectra
No Data Available
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References
• Ordonez Gallego A, Gonzalez Baron M, Espinosa Arranz E: Oxycodone: a pharmacological and clinical review. Clin Transl Oncol. 2007 May;9(5):298-307. Pubmed
• Riley J, Eisenberg E, Muller-Schwefe G, Drewes AM, Arendt-Nielsen L: Oxycodone: a review of its use in the management of pain. Curr Med Res Opin. 2008 Jan;24(1):175-92. Pubmed