Molecule

Drug Groups

illicit; approved; investigational

Description

Semisynthetic derivative of codeine that acts as a narcotic analgesic more potent and addicting than codeine. [PubChem]

Indication

For the treatment of diarrhoea, pulmonary oedema and for the relief of moderate to moderately severe pain.

Pharmacology

Oxycodone, a semisynthetic opiate agonist derived from the opioid alkaloid, thebaine, is similar to other phenanthrene derivatives such as hydrocodone and morphine. Oxycodone is available in combination with aspirin or acetaminophen to control pain and restless leg and Tourette syndromes.

Toxicity

Symptoms of overdose include respiratory depression, somnolence progressing to stupor or coma, skeletal muscle flaccidity, cold and clammy skin, constricted pupils, bradycardia, hypotension, and death.

Affected Organisms

Biotransformation

Hepatic

Absorption

Well absorbed with an oral bioavailability of 60% to 87%

Half Life

4.5 hours

Protein Binding

45%

Elimination

Oxycodone and its metabolites are excreted primarily via the kidney.

Distribution

* 2.6 L/kg

Clearance

* 0.8 L/min [adults]

References

External Links