Substance
ID:355092
Names and Identifiers
Synonyms
2-AcetamidofluoreneN-Acetyl-2-aminofluoreneN-(2-Fluorenyl)acetamideN-乙酰基-2-氨基芴2-AAF2-乙酰氨基芴N-(2-芴基)乙酰胺
IUPAC name
N-(9H-fluoren-2-yl)acetamide
IUPAC Traditional name
2 acetylaminofluorene
Registration numbers
Beilstein Number
CAS Number
MDL Number
EC Number
Properties
Product Information
Empirical Formula (Hill Notation)
C15H13NO
Grade
purum
Purity
≥95.0% (CHN)
Safety Information
GHS Pictograms
Respiratory sensitization, category 1
Germ cell mutagenicity, categories 1A,1B,2
Carcinogenicity, categories 1A,1B,2
Reproductive toxicity, categories 1A,1B,2
Specific Target Organ Toxicity – Single exposure, categories 1,2
Specific Target Organ Toxicity – Repeated exposure, categories 1,2
Aspiration Hazard, category 1
Acute toxicity (oral, dermal, inhalation), category 4
Skin irritation, category 2
Eye irritation, category 2
Skin sensitisation, category 1
Specific Target Organ Toxicity – Single exposure, category 3
GHS Signal Word
Danger
GHS Precautionary statements
P201-P308+P313
German water hazard class
3
European Hazard Symbols
Toxic (T)GHS Hazard statements
H302-H350
RTECS
AB9450000
Safety Statements
53-36/37/39-45
Packing Group
3
Personal Protective Equipment
Eyeshields, full-face particle respirator type N100 (US), Gloves, respirator cartridge type N100 (US), type P1 (EN143) respirator filter, type P3 (EN 143) respirator cartridges
RID/ADR
UN 3077 9/PG 3
Hazard Class
9
UN Number
3077
MSDS Link
Risk Statements
45-22
Physical Property
Melting Point
192-196 °C(lit.)
Molecule Details
Biochem/physiol Actions
A genotoxic carcinogen that is used to model liver carcinogenesis in rat. When N-hydroxylated by cytochrome CYP1A2 in the liver, 2-AAF forms adducts with DNA and is tumorigenic in liver and bladder.
Application
N-(2-fluorenyl)acetamide is a hepatic carcinogen whose principle target protein is the liver fatty acid binding protein (L-FABP). N-(2-Fluorenyl)acetamide has been used in a study to establish a hepatoma model to study the dynamic expression and quantitative analysis of hepatic nuclear factor-kappa B and its gene during the development of hepatocellular carcinoma.
A genotoxic carcinogen that is used to model liver carcinogenesis in rat. When N-hydroxylated by cytochrome CYP1A2 in the liver, 2-AAF forms adducts with DNA and is tumorigenic in liver and bladder.
Application
N-(2-fluorenyl)acetamide is a hepatic carcinogen whose principle target protein is the liver fatty acid binding protein (L-FABP). N-(2-Fluorenyl)acetamide has been used in a study to establish a hepatoma model to study the dynamic expression and quantitative analysis of hepatic nuclear factor-kappa B and its gene during the development of hepatocellular carcinoma.
Molecular Spectra
No Data Available
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References
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