Molecule

2-Acetylaminofluorene 

A4109 

Biochem/physiol Actions
A genotoxic carcinogen that is used to model liver carcinogenesis in rat. When N-hydroxylated by cytochrome CYP1A2 in the liver, 2-AAF forms adducts with DNA and is tumorigenic in liver and bladder.
Warning
OSHA-regulated carcinogen - 29 CFR Part 1910.1014

A7015 

Biochem/physiol Actions
A genotoxic carcinogen that is used to model liver carcinogenesis in rat. When N-hydroxylated by cytochrome CYP1A2 in the liver, 2-AAF forms adducts with DNA and is tumorigenic in liver and bladder.

00300 

Biochem/physiol Actions
A genotoxic carcinogen that is used to model liver carcinogenesis in rat. When N-hydroxylated by cytochrome CYP1A2 in the liver, 2-AAF forms adducts with DNA and is tumorigenic in liver and bladder.
Application
N-(2-fluorenyl)acetamide is a hepatic carcinogen whose principle target protein is the liver fatty acid binding protein (L-FABP). N-(2-Fluorenyl)acetamide has been used in a study to establish a hepatoma model to study the dynamic expression and quantitative analysis of hepatic nuclear factor-kappa B and its gene during the development of hepatocellular carcinoma.

CHEBI:17356 

The parent of the class of 2-acetamidofluorenes, being an ortho-fused polycyclic arene that consists of 9H-fluorene bearing an acetamido substituent at position 2. It is a carcinogenic and mutagenic derivative of fluorene.